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To test this, postnatal day (PND)-15 rat pups were either treated with Luria Bertani broth\/Escherichia coli OP50\/C. sakazakii through oral gavage or maintained as control and allowed to stay with their mothers until PND-24. Experimental groups\u2019 rats were subjected to long-term novel object recognition test during their adolescent age PND-30\u201332. Observed behavioral data showed that C. sakazakii infection causes a deficit in recognition of novel objects from known objects. Further, our analysis showed that C. sakazakii infection-mediated inflammation decreases the Reelin expression by proteolytic cleavage and alters its receptor apolipoprotein E-receptor (ApoER)-2 splice variants ApoER2 (ex19) and ApoER2 (\u0394). Subsequently, downregulated Reelin alters the phosphorylation of disabled adapter protein (Dab)-1 and leads to differential expression of N-methyl-D-aspartate (NMDA) receptor subunits 2A and 2B. Further, the NMDA receptor influences the expression of postsynaptic density (PSD)-95 protein and brain-derived neurotrophic factor (BDNF). Observed results suggest a deficit in recognition of novel objects possibly due to the alternation in Reelin signaling pathway. <\/jats:p>","DOI":"10.1159\/000525821","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T21:00:32Z","timestamp":1657227632000},"page":"547-556","source":"Crossref","is-referenced-by-count":6,"title":["Reduced Reelin Expression Induces Memory Deficits through Dab-1\/ NMDAR Signaling Pathway: Cronobacter sakazakii Infection in a Rat Model of Experimental Meningitis"],"prefix":"10.1159","volume":"44","author":[{"given":"Ponnusamy","family":"Vinay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnaswamy","family":"Balamurugan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koilmani 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