{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:45:33Z","timestamp":1780317933434,"version":"3.54.1"},"reference-count":53,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<b><i>Introduction:<\/i><\/b> Traumatic brain injury (TBI) has been associated with a greater risk of developing Alzheimer\u2019s disease (AD). Less is known about the clinical features of AD patients with TBI history. The objective of this study was to examine whether a history of TBI and specific injury characteristics are associated with differences in age of disease onset, cognitive features, and neuropsychiatric symptoms (NPSs) in AD patients. <b><i>Methods:<\/i><\/b> Biomarker-proven AD patients (CSF or amyloid PET) were selected from the Amsterdam Dementia Cohort. TBI events were classified by age at injury (TBI &#x3c;25 or \u226525 years) and TBI severity (loss of consciousness, multiple events). Cognitive composite scores were calculated from results of a neuropsychological test battery. NPSs were assessed with the Neuropsychiatric Inventory Questionnaire (NPI-Q). Linear regression analyses were utilized to examine associations between TBI, TBI characteristics, and clinical outcome measures. <b><i>Results:<\/i><\/b> Among the 1,755 selected AD patients (mean age = 65.2 years), 166 (9.5%) had documented \u22651 TBI in their medical history. Overall, TBI history was not related to differences in age of disease onset, but age at injury &#x3c;25 years old was associated with 2.3 years earlier age at symptom onset (<i>B<\/i> = \u22122.34, <i>p<\/i> = 0.031). No significant associations were found between TBI history or TBI characteristics and differences in cognition or NPSs. <b><i>Conclusion:<\/i><\/b> Our results underscore previous findings on the vulnerability of the brain during critical maturation phases and suggest that an early TBI may contribute to lower resilience to neurodegenerative changes. <\/jats:p>","DOI":"10.1159\/000526243","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T21:00:34Z","timestamp":1663362034000},"page":"122-130","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Features of Patients with Alzheimer\u2019s Disease and a History of Traumatic Brain Injury"],"prefix":"10.1159","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-6276","authenticated-orcid":false,"given":"Suzan","family":"van Amerongen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-6595","authenticated-orcid":false,"given":"Dewi K.","family":"Caton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A.L.","family":"Pijnenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everard G.B.","family":"Vijverberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"ref1"},{"key":"ref2"},{"key":"ref3"},{"key":"ref4"},{"key":"ref5"},{"key":"ref6"},{"key":"ref7"},{"key":"ref8"},{"key":"ref9"},{"key":"ref10"},{"key":"ref11"},{"key":"ref12"},{"key":"ref13"},{"key":"ref14"},{"key":"ref15"},{"key":"ref16"},{"key":"ref17"},{"key":"ref18"},{"key":"ref19"},{"key":"ref20"},{"key":"ref21"},{"key":"ref22"},{"key":"ref23"},{"key":"ref24"},{"key":"ref25"},{"key":"ref26"},{"key":"ref27"},{"key":"ref28"},{"key":"ref29"},{"key":"ref30"},{"key":"ref31"},{"key":"ref32"},{"key":"ref33"},{"key":"ref34"},{"key":"ref35"},{"key":"ref36"},{"key":"ref37"},{"key":"ref38"},{"key":"ref39"},{"key":"ref40"},{"key":"ref41"},{"key":"ref42"},{"key":"ref43"},{"key":"ref44"},{"key":"ref45"},{"key":"ref46"},{"key":"ref47"},{"key":"ref48"},{"key":"ref49"},{"key":"ref50"},{"key":"ref51"},{"key":"ref52"},{"key":"ref53"}],"container-title":["Dementia and Geriatric Cognitive Disorders Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/526243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/526243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:14:03Z","timestamp":1745421243000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000526243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,12,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000526243","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.21129775","asserted-by":"subject"}]},"ISSN":["1664-5464"],"issn-type":[{"value":"1664-5464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,16]]}}}