{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:59:57Z","timestamp":1772164797204,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lifestyle Genomics"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Arachidonic acid (ARA) is associated with colorectal cancer (CRC), a major public health concern. However, it is uncertain if ARA contributes to the development of colorectal polyps which are pre-malignant precursors of CRC. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The study aimed to investigate the association between lifelong exposure to elevated ARA and colorectal polyp incidence. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Summary-level GWAS data from European, Singaporean, and Chinese cohorts (&lt;i&gt;n&lt;\/i&gt; = 10,171) identified 4 single-nucleotide polymorphisms (SNPs) associated with blood ARA levels (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 5 \u00d7 10&lt;sup&gt;\u22128&lt;\/sup&gt;). After pruning, 1 SNP was retained (rs174547; &lt;i&gt;p&lt;\/i&gt; = 3.0 \u00d7 10&lt;sup&gt;\u2212971&lt;\/sup&gt;) for 2-stage Mendelian randomization. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; No association between ARA and colorectal polyp incidence was observed (OR = 1.00; 95% CI: 0.99, 1.00; &lt;i&gt;p&lt;\/i&gt; value = 0.50) within the UK Biobank (1,391 cases; 462,933 total). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Blood levels of ARA do not associate with colorectal polyp incidence in a general healthy population. Although not providing direct evidence, this work supports the contention that downstream lipid mediators, such as PGE&lt;sub&gt;2&lt;\/sub&gt; rather than ARA itself, are key for polyp formation during early-stage colorectal carcinogenesis.<\/jats:p>","DOI":"10.1159\/000526447","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T17:00:34Z","timestamp":1660237234000},"page":"107-110","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Association between High Arachidonic Acid Synthesis and Colorectal Polyp Incidence within a Generally Healthy UK Population: A Mendelian Randomization Approach"],"prefix":"10.1159","volume":"15","author":[{"given":"Rachel","family":"Moon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-1550","authenticated-orcid":false,"given":"J. Bernadette","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-1576","authenticated-orcid":false,"given":"Mark A.","family":"Hull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4944-5521","authenticated-orcid":false,"given":"Michael A.","family":"Zulyniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"ref1"},{"key":"ref2"},{"key":"ref3"},{"key":"ref4"},{"key":"ref5"},{"key":"ref6"},{"key":"ref7"},{"key":"ref8"},{"key":"ref9"},{"key":"ref10"},{"key":"ref11"},{"key":"ref12"},{"key":"ref13"},{"key":"ref14"},{"key":"ref15"},{"key":"ref16"}],"container-title":["Lifestyle Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/526447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/526447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:16:07Z","timestamp":1745406967000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000526447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,11,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000526447","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.04.11.22273669","asserted-by":"object"}]},"ISSN":["2504-3161","2504-3188"],"issn-type":[{"value":"2504-3161","type":"print"},{"value":"2504-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}