{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:39:40Z","timestamp":1783647580766,"version":"3.55.0"},"reference-count":85,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: There is increasing evidence on the prognostic significance of D-dimer and fibrinolysis in stroke. However, the systematic analysis of their relationship with adverse outcomes after stroke is lacking. Herein, we comprehensively assessed the correlation of D-dimer and fibrinolysis with stroke outcomes through meta-analysis. Methods: Studies for systematic literature review were retrieved from PubMed, EMBASE, and Cochrane Library databases. The association of D-dimer and fibrinolysis with outcomes of stroke patients was expressed as an odds ratio (OR) with 95% confidence intervals (95% CI). Results: Totally, 52 studies comprising 21,473 stroke patients were included. The results showed that the high D-dimer level was significantly associated with peripheral venous thrombosis after stroke (OR 1.03, 95% CI 1.01\u20131.05), poor outcome (MRS &gt;2) after stroke (OR 1.731, 95% CI 1.464\u20132.048), death after stroke (OR 2.367, 95% CI 1.737\u20133.224), stroke recurrence (OR 1.229, 95% CI 1.113\u20131.358), and early neurologic deterioration (NIHSS &gt;4) (OR 1.791, 95% CI 1.117\u20132.870). Moreover, high fibrinogen level was significantly associated with poor outcome (MRS &gt;2) after stroke (OR 1.650, 95% CI 1.314\u20132.071), death after stroke (OR 1.310, 95% CI 1.128\u20131.520), stroke recurrence (OR 1.228, 95% CI 1.166\u20131.422), early neurologic deterioration (NIHSS &gt;4) (OR 2.381, 95% CI 1.156\u20134.904), and coronary events after stroke (OR 1.427, 95% CI 1.232\u20131.653). Conclusion: Fibrinogen and D-dimer may be associated with adverse outcomes in patients with stroke, suggesting that they may serve as possible biomarkers for post-stroke adverse outcomes. <\/jats:p>","DOI":"10.1159\/000526476","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T21:00:31Z","timestamp":1666645231000},"page":"318-343","source":"Crossref","is-referenced-by-count":26,"title":["Clinical Significance of Plasma D-Dimer and Fibrinogen in Outcomes after Stroke: A Systematic Review and 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