{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:15:12Z","timestamp":1792512912655,"version":"4.5.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The link between the effects of recombinant human growth hormone (rhGH) therapy in patients with growth hormone deficiency (GHD) and Chiari malformation type I (CM-1) is controversial. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; We report the case of a patient with an unusual association of GHD due to ectopic posterior pituitary and CM-1. Our patient developed a headache and worsening of CM-1 after the initiation of rhGH therapy. Following an atlo-occipital decompression surgery, the patient was able to resume therapy with a marked growth improvement. Based on this observation, we provide a systematic review of the current literature about these two pathologies. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; A careful follow-up of all patients with CM-1 treated with GH is mandatory, paying particular attention to the appearance of any neurological signs and symptoms. <\/jats:p>","DOI":"10.1159\/000526617","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T21:00:26Z","timestamp":1661374826000},"page":"349-355","source":"Crossref","is-referenced-by-count":5,"title":["Can GH Therapy Worsen a Clinically Silent Chiari Malformation? A Case Report and Systematic Literature Review"],"prefix":"10.1159","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-9314","authenticated-orcid":false,"given":"Egidio","family":"Candela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-8629","authenticated-orcid":false,"given":"Emanuele","family":"La Corte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-7170","authenticated-orcid":false,"given":"Stefano","family":"Zucchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Lefosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Toni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-355X","authenticated-orcid":false,"given":"Mino","family":"Zucchelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2015.06.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100010507"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2005.02.021"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.12.020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3171\/2010.12.PEDS10379"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.11.002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000197875"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-007-0374-x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344156"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30163-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000110474"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2002.15.s2.723"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-019-04296-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-008-0675-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.30.49"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.4.0708"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000028760"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-14-28"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-38-48"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03157.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00128.hilal"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.079"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-013-2080-1"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/BF02072226"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.43.suppl_s129"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000097562"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.27.45"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-020-04531-8"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05347-3"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90193-6"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000126813"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1159\/000070416"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.1.0040"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1081"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/96\/4\/349\/3992456\/000526617.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/96\/4\/349\/3992456\/000526617.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:17:39Z","timestamp":1745421459000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000526617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,8,28]]},"published-print":{"date-parts":[[2023,8,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000526617","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.20590092","asserted-by":"subject"}]},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]}}}