{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:26:21Z","timestamp":1769347581830,"version":"3.49.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Objectives: Bladder cancer is a common type of malignancy. UBC\u00aeRapid is a novel immunoassay detecting urine cytokeratin 8\/18 protein. Studies have shown good accuracy of UBC\u00aeRapid in detecting bladder cancer. UBC\u00aeRapid has however to date not been evaluated in Asian patients. We evaluated UBC\u00aeRapid in detecting Asian bladder cancer, together with urine cytology. Methods: In total, 112 patients were recruited from National University Hospital Singapore and 103 patients were included in this study, comprising 49 patients with bladder urothelial carcinoma (UC), 21 patients with bladder benign lesions, and 33 patients with normal bladder. All the bladder cancer and benign lesions were confirmed by histology. Voided urine was collected for UBC\u00aeRapid test. The results were compared with urine cytology. Results: The bladder UC group had remarkably higher UBC\u00aeRapid value than the control groups. The sensitivity, specificity, positive, and negative predictive value of UBC\u00aeRapid in detecting bladder UC were 53%, 85.5%, 76.5%, and 66.8%, respectively. Those of urine cytology were 40.8%, 96.3%, 90.9%, and 64.2%, respectively. Adding UBC\u00aeRapid to urine cytology increased sensitivity to 57.1% but decreased specificity to 81.8%. UBC\u00aeRapid was sensitive in detecting high-grade bladder UC (61.1%) and carcinoma in situ (CIS) (72.7%), as compared to urine cytology for bladder UC (55.6%) and CIS (54.5%), respectively. Conclusion: UBC\u00aeRapid is sensitive in detecting high-grade bladder UC and CIS in Asian population. It may be useful as an adjunct test to achieve better detection of bladder cancer. <\/jats:p>","DOI":"10.1159\/000526763","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T21:00:35Z","timestamp":1666386035000},"page":"29-34","source":"Crossref","is-referenced-by-count":3,"title":["UBC\u00aeRapid Is Sensitive in Detecting High-Grade Bladder Urothelial Carcinoma and Carcinoma in situ in Asian Population"],"prefix":"10.1159","volume":"107","author":[{"given":"Zhijiang","family":"Zang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha Raishmi","family":"Kesavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kesavan","family":"Esuvaranathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.07.076"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000273465"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0302-2838(01)00015-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90400-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317701624"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14389"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2017.1313309"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000511447"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2007.06.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.19929"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.09.024"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-4295(99)00383-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.08.019"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199904000-00016"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/uin\/article-pdf\/107\/1\/29\/3954345\/000526763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/uin\/article-pdf\/107\/1\/29\/3954345\/000526763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:19:17Z","timestamp":1745421557000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000526763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,23]]},"published-print":{"date-parts":[[2023,1,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000526763","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]}}}