{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:19Z","timestamp":1747193599125,"version":"3.40.5"},"reference-count":40,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Over 90% of the patients with familial adenomatous polyposis (FAP) will develop duodenal adenomas. &lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to evaluate the effectiveness and safety of endoscopic excision of large duodenal adenomas in FAP patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; All FAP patients from a familial risk clinic submitted to endoscopic therapy for duodenal adenomas \u226510 mm between January 2010 and February 2021 were included. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; From 151 FAP families, 22 patients (50 lesions) were included: 54.5% female; median follow-up 8.5 (IQR: 5.8\u201312.3) years after the first endoscopy. First therapeutic endoscopy occurred at a median age of 41.0 years (IQR: 33.0\u201358.2). Repeat therapeutic endoscopy was required in 54.5% of patients. Median size of the largest adenoma was 15 mm (IQR: 10\u201318 mm); resection was piecemeal in 63.1% and en bloc in the remaining. In 2 cases, the resection was incomplete (fibrosis due to previous resection and difficult positioning). Complications occurred in 6.3% of the resected lesions (4 patients): 2 immediate (bleeding, perforation); 4 in the first week (1 bleeding, 2 mild pancreatitis, 1 perforation requiring surgery; the latter two after ampullectomy). Histology revealed low-grade dysplasia adenomas in 90.1%; no adenocarcinomas were found. One patient with Spigelman stage IV disease not amenable to endoscopic control underwent elective duodenopancreatectomy (without duodenal cancer). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Endoscopic surveillance and treatment of duodenal adenomas in FAP patients was safe and effective in the prevention of duodenal cancer. <\/jats:p>","DOI":"10.1159\/000527209","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T06:32:52Z","timestamp":1669789972000},"page":"430-436","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic Approach to Duodenal Adenomas in Familial Adenomatous Polyposis: A Retrospective Cohort"],"prefix":"10.1159","volume":"30","author":[{"given":"Joana","family":"Lemos Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-5987","authenticated-orcid":false,"given":"Isadora","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Pereira da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Lage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Claro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9433-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-17-1269"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02844.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.027771"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-41"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.6.716"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.422"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)61155-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)90840-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.136127"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/dcr.0000000000000912"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz233"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.435"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/a-0965-0605"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro17.2015.12.031"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.03.1467"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2016(01)06"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-2996-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3467-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000000734"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.04.061"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.01.028"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-013-9648-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.10.035"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200006293422603"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.857"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa012015"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.capr-17-0130"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa061652"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.2522"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1077619"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.06.018"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.11.038"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.116564"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(03)02366-6"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.04.053"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.121881"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1055\/a-1397-3198"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1055\/a-1442-2395"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1159\/000512360"}],"container-title":["GE - 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