{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:09:45Z","timestamp":1779019785958,"version":"3.51.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4-6","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Purpose: Orbital plasmacytoma is a tumor of plasma cells located in the orbit, which is uncommon and only accounts for less than 1% of total orbital tumors. Sixty-five percent of orbital plasmacytoma are carrying a diagnosis of multiple myeloma. We hereby present two aggressive orbital plasmacytoma cases, a rare orbital malignancy with unsatisfactory outcomes. Methods: This is a series of two orbital plasmacytoma cases. Both initial complaints were unilateral rapid onset of non-axial proptosis with palpable mass in the superior orbit. The first case was IgA-type multiple myeloma with multiple secondary plasmacytomas diagnosed based on systemic evaluation showing hyperproteinemia, IgA level elevation with free \u03ba-light chains, and multiple destructive osteolytic lesions. The second patient unfortunately died before systemic evaluation was carried out. Results: Both patients died less than 2 months after diagnosis, underscoring a very poor prognosis. It is important to perform systemic evaluation and appropriate treatment immediately once the diagnosis has been established. Conclusions: Orbital plasmacytoma is a rare orbital malignancy and is commonly secondary to systemic multiple myeloma. Ophthalmologists should have a high index of suspicion as it has a nonspecific presentation and consider it as one of the differential diagnoses in orbital tumors. <\/jats:p>","DOI":"10.1159\/000527273","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T21:00:30Z","timestamp":1665608430000},"page":"197-202","source":"Crossref","is-referenced-by-count":6,"title":["A Case Series of Aggressive Orbital Plasmacytomas"],"prefix":"10.1159","volume":"8","author":[{"given":"Nizma","family":"Permaisuari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-1036","authenticated-orcid":false,"given":"Neni","family":"Anggraini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutmainah","family":"Mahyuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelina","family":"Kodrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wulyo","family":"Rajabto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.04.012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-3-19"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v5i9.482"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.73645"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.15274\/nrj-2014-10078"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-220895"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-015-0264-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2013.839807"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0049"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-123"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/edbk_159009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2019.03.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.231513"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/oop\/article\/8\/4-6\/197\/835430\/A-Case-Series-of-Aggressive-Orbital-Plasmacytomas","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/oop\/article\/8\/4-6\/197\/835430\/A-Case-Series-of-Aggressive-Orbital-Plasmacytomas","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:24:41Z","timestamp":1745421881000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000527273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":13,"journal-issue":{"issue":"4-6","published-online":{"date-parts":[[2023,2,16]]},"published-print":{"date-parts":[[2023,2,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000527273","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}