{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:11:30Z","timestamp":1768813890860,"version":"3.49.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Remnant cholesterol is a risk factor for cardiovascular disease, especially when low-density lipoprotein cholesterol (LDL-C) levels are normal. However, there are few studies on the relationship between remnant cholesterol and subclinical atherosclerosis. Common carotid artery intima-media thickness (cIMT) is an imaging marker of subclinical atherosclerosis. This study aimed to investigate the relationship between remnant cholesterol and cIMT in a community population with normal LDL-C. Methods: This study is a retrospective analysis; 1,101 community population with available carotid artery imaging and fasting lipid data with LDL-C &lt;4.1 mmol\/L were included in this analysis. Remnant cholesterol was calculated as total cholesterol minus LDL-C minus high-density lipoprotein cholesterol. Abnormal cIMT was defined as maximum cIMT value \u22651 mm. Logistic regression was used to assess the relationships between remnant cholesterol levels and abnormal cIMT. Results: As the remnant cholesterol level increased from the lowest to the highest quartile, the rate of abnormal cIMT increased from 24.5% to 38.6% (p trend &lt;0.001) in the community population with normal LDL-C level. In the unadjusted model, the odds ratios (ORs, 95% confidence intervals) in the highest quartile group were 1.937 (1.338\u20132.803) for abnormal cIMT compared with the lowest quartile. The multivariable-adjusted ORs (95% confidence intervals) for the highest versus lowest quartile of remnant cholesterol were 2.132 (1.420\u20133.202) for abnormal cIMT. Conclusion: Elevated fasting remnant cholesterol levels were positively associated with abnormal cIMT in community population with normal LDL-C levels. Remnant cholesterol may be an important indicator of risk stratification in community population with normal LDL-C level. <\/jats:p>","DOI":"10.1159\/000527704","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T22:00:37Z","timestamp":1675720837000},"page":"487-494","source":"Crossref","is-referenced-by-count":4,"title":["Remnant Cholesterol and Common Carotid Artery Intima-Media Thickness in Community Population with Normal Low-Density Lipoprotein Cholesterol"],"prefix":"10.1159","volume":"52","author":[{"given":"Yan","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Litao","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.034"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr112"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.115.002765"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.117.310269"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.116.308305"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00470"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.118.008740"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13537"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs431"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)61177-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.119.026587"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.4873"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.119.024968"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.09.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.120.010953"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000154900.76284.f6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/24.10.1724"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.02.019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.08.018"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000343145"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-8622-8_8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000117403.64398.53"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000093221"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.5551\/jat.63397"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-5-20"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-010-3408-1"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ced\/article-pdf\/52\/4\/487\/3994926\/000527704.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ced\/article-pdf\/52\/4\/487\/3994926\/000527704.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:30:06Z","timestamp":1745422206000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000527704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,9,1]]},"published-print":{"date-parts":[[2023,9,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000527704","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}