{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:32:56Z","timestamp":1747193576826,"version":"3.40.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown. Objectives: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics. Methods: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed. Results: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics. Conclusion: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice. <\/jats:p>","DOI":"10.1159\/000528259","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T22:00:38Z","timestamp":1672351238000},"page":"434-440","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics"],"prefix":"10.1159","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-6582","authenticated-orcid":false,"given":"Anxiang","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Placier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane","family":"Louedec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perrine","family":"Fr\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souhila","family":"Ouchelouche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Chatziantoniou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-6153","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Calmont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21301-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2012.02.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80534-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27363"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79668"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.12.028"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000513942"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20829-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv276"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.06.026"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110041"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147284"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401004010302"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1979-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800499R"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1042\/cs20000012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021081150"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101677"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/nef\/article-pdf\/147\/7\/434\/3964709\/000528259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/nef\/article-pdf\/147\/7\/434\/3964709\/000528259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:35:52Z","timestamp":1745422552000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000528259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7,13]]},"published-print":{"date-parts":[[2023,7,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000528259","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.21788999","asserted-by":"subject"}]},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"type":"print","value":"1660-8151"},{"type":"electronic","value":"2235-3186"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}