{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:00Z","timestamp":1747193580556,"version":"3.40.5"},"reference-count":53,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Modern intravenous iron compounds (e.g., ferric carboxymaltose [FCM] and ferric derisomaltose [FDI]) are utilized in the treatment of iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD). Product-specific alterations in the metabolism of fibroblast growth factor 23 (FGF-23) leading to hypophosphatemia have been described for certain intravenous iron compounds, such as FCM, with potential effects on bone and cardiovascular health and quality of life. No prior head-to-head comparison between FCM and FDI exists in ND-CKD. This single-center exploratory double-blind randomized controlled trial primarily aimed to investigate the differential impact of FCM and FDI on FGF-23 and phosphate in patients with iron deficiency +\/\u2212 anemia and ND-CKD (stages 3a\u20135 \u2013 serum ferritin &amp;lt;200 \u03bcg\/L or serum ferritin 200\u2013299 \u03bcg\/L and transferrin saturation &amp;lt;20%). Patients were randomized (1:1) to receive either FCM or FDI over two infusions (1 month apart). Follow-up was 3 months. Measurements of serum intact FGF-23, phosphate, vitamin D metabolites, parathyroid hormone, other bone metabolism, cardiovascular, and quality of life markers were monitored. 168 patients were prescreened. Thirty-five patients were screened; 26 patients were randomized. The mean (standard deviation) age was 67.9 (12.4) years and 17 participants were male. Most participants had stage 4 CKD (median [interquartile range] estimated glomerular filtration rate [eGFR]: 18.0 [11.3] mL\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;). A higher than normal median (interquartile range) level of intact FGF-23 (212.1 [116.4] pg\/mL) was noted. Serum phosphate was within normal range, while parathyroid hormone was higher and 1,25 (OH)&lt;sub&gt;2&lt;\/sub&gt; vitamin D lower than the normal range. The \u201cIron and Phosphaturia \u2013 ExplorIRON-CKD\u201d trial will provide important information regarding the differential effect of intravenous iron products in terms of FGF-23, phosphate, and other markers of bone and cardiovascular metabolism, alongside patient-reported outcome measures in patients with ND-CKD. <\/jats:p>","DOI":"10.1159\/000528313","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T21:01:03Z","timestamp":1680642063000},"page":"151-164","source":"Crossref","is-referenced-by-count":3,"title":["Methodology and Baseline Data of a Comparative Exploratory Double-Blinded Randomized Study of Intravenous Iron on Fibroblast Growth Factor 23 and Phosphate in Chronic Kidney 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