{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:21Z","timestamp":1747193601911,"version":"3.40.5"},"reference-count":9,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>I report a case with ocular Beh\u00e7et disease presenting as hypopyon-anterior uveitis refractory to conventional immunosuppressive drugs who was safely and effectively managed for 20 years by nonstop infusions of a modern anti-TNF agent, infliximab. A 14-year-old girl who had a history of recurrent oro-genital ulcers, arthralgia, and pathergy test positivity presented with the symptoms of bilateral blurred vision, ocular pain, photophobia, and lacrimation. Initial visual acuities were 20\/25 bilaterally, and biomicroscopy revealed bilateral iridocyclitis with left shifting cold hypopyon formation in the anterior chamber of the eye. The diagnosis of ocular Beh\u00e7et disease was made, and topical anti-inflammatory drops were initiated with a cycloplegic agent. In due course, the child complained of chronic floaters and decreased vision from 20\/25 to 20\/200 bilaterally. Vitreitis, retinitis, perivasculitis, and cystoid macular edema (CME) were encountered, and the combination of corticosteroid, azathioprine, and cyclosporine-A was immediately started. However, the child did not respond to this conventional management for 3 months. A prompt and dramatic response was obtained with repeated Remicade\u00ae (infliximab) infusions (weeks 0, 2, 6, and 10), which led to fast improvement in her systemic and ocular symptoms. Long-term remission of 20 years was obtained by regular infliximab infusions at each 6- to 9-week interval with stabilized vision (20\/20) and resolution of CME. The present case shows the significant role of biologicals in pediatric severe panuveitis and that nonstop infliximab infusions initiated early led to rapid and long-term control of intraocular inflammation and recurrent sight-threatening uveitis attacks for protecting the vision in children with severe OBD. <\/jats:p>","DOI":"10.1159\/000528593","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:15:56Z","timestamp":1697663756000},"page":"75-82","source":"Crossref","is-referenced-by-count":7,"title":["Twenty Years of Quiescence after Nonstop Remicade\u00ae (Infliximab) Infusions in a Child with Ocular Beh\u00e7et Disease Presenting as Hypopyon-Anterior Uveitis Refractory to Immunosuppressants"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-4532","authenticated-orcid":false,"given":"Cem","family":"Evereklioglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016\/j.survophthal.2005.04.009"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1111\/j.1365-4632.2006.02754.x"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1517\/14656566.5.2.317"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1111\/jdv.12107"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1080\/09629350220131935"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1097\/ICU.0b013e32834bbe91"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016\/j.ajo.2022.02.002"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016\/j.jaut.2020.102481"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.2165\/11538330-000000000-00000"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cop\/article-pdf\/14\/1\/75\/3980524\/000528593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cop\/article-pdf\/14\/1\/75\/3980524\/000528593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:04:28Z","timestamp":1745420668000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000528593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":9,"URL":"https:\/\/doi.org\/10.1159\/000528593","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.22093760","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"type":"electronic","value":"1663-2699"}],"subject":[],"published":{"date-parts":[[2023,2,22]]}}}