{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:59:17Z","timestamp":1787061557282,"version":"build-2736575974"},"reference-count":34,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: This study examined the difference in overall survival (OS) between peritoneal metastatic gastric cancer (PMGC) patients who underwent neoadjuvant chemotherapy followed by cytoreductive surgery \u00b1 hyperthermic intraperitoneal chemotherapy (CRS \u00b1 HIPEC) and those who did not have surgery but instead received palliative chemotherapy. Methods: This retrospective study included 80 patients who were followed up with the diagnosis of PMGC, those undergoing neoadjuvant chemotherapy followed by CRS \u00b1 HIPEC (CRS \u00b1 HIPEC group) and those receiving chemotherapy only (non-surgical group), in the medical oncology clinic between April 2011 and December 2021. Clinicopathological features, treatments, and OS of the patients were compared. Results: There were 32 patients in the SRC CRS \u00b1 HIPEC group and 48 in the non-surgical group. In the CRS \u00b1 HIPEC group, CRS + HIPEC was performed on 20 patients, and only CRS was performed on 12 patients. All of the patients who underwent CRS + HIPEC, and 5 of the patients who underwent only CRS received neoadjuvant chemotherapy. While the median OS was 19.7 (15.5\u201323.8) months in the CRS \u00b1 HIPEC group, the median OS was 6.8 (3.5\u201310.2) months in the non-surgical group (p &amp;lt; 0.001). Conclusion: As a result, CRS + HIPEC significantly improves survival in PMGC patients. With experienced surgical centres and appropriate patient selection, the life expectancy of patients with PM can be extended.<\/jats:p>","DOI":"10.1159\/000528609","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T17:03:58Z","timestamp":1676999038000},"page":"321-327","source":"Crossref","is-referenced-by-count":11,"title":["Neoadjuvant Chemotherapy Followed by Cytoreductive Surgery and HIPEC Improves Survival in Peritoneal Metastatic Gastric Cancer"],"prefix":"10.1159","volume":"101","author":[{"given":"Selin","family":"Akturk Esen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigit Mehmet","family":"Ozgun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-6702","authenticated-orcid":false,"given":"Denizcan","family":"Hasturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-1075","authenticated-orcid":false,"given":"Gokhan","family":"Ucar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal Birol","family":"Bostanci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali Nahit","family":"Sendur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dogan","family":"Uncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21324"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.03.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890115)63:2%3c364::aid-cncr2820630228%3e3.0.co;2-v"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198807000-00005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0055-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0137"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6125-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1081-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2013.04.004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5081-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07450-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21068"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-016-0622-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.154"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70035-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.877"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1631-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01688"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24248"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25356"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21052"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-2020-04"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1039-7"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4695"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2003.12.014"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.8613"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.06.12"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.03.007"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28204"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.05.015"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.05.016"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0478-5"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ocl\/article-pdf\/101\/5\/321\/3965149\/000528609.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ocl\/article-pdf\/101\/5\/321\/3965149\/000528609.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:04:41Z","timestamp":1745406281000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000528609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,5,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000528609","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}