{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:21:42Z","timestamp":1792171302823,"version":"4.4.0"},"reference-count":57,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Specific multimorbidity combinations, in particular those including arthritis, stroke, and cognitive impairment, have been associated with high burden of activities of daily living (ADL)-instrumental activities of daily living (IADL) disability in older adults. The biologic underpinnings of these associations are still unclear. Methods: Observational longitudinal study using data from the Health and Retirement Study (N = 8,618, mean age = 74 years, 58% female, 25% non-white) and negative binomial regression models stratified by sex to evaluate the role of inflammatory and glycemic biomarkers (high-sensitivity C-reactive protein (hs-CRP) and HbA1c) in the association between specific multimorbidity combinations (grouped around one of eight index diseases: arthritis, cancer, cognitive impairment, diabetes, heart disease, hypertension, lung disease, and stroke; assessed between 2006 and 2014) and prospective ADL-IADL disability (2 years later, 2008\u20132016). Results were adjusted for sociodemographic characteristics, body mass index, number of coexisting diseases, and baseline ADL-IADL score. Results: Multimorbidity combinations indexed by arthritis (IRR = 1.1, 95% CI = 1.01\u20131.20), diabetes (IRR = 1.19, 95% CI = 1.09\u20131.30), and cognitive impairment (IRR = 1.11, 95% CI = 1.01\u20131.23) among men and diabetes-indexed multimorbidity combinations (IRR = 1.07, 95% CI = 1.01\u20131.14) among women were associated with higher ADL-IADL scores at increasing levels of HbA1c. Across higher levels of hs-CRP, multimorbidity combinations indexed by arthritis (IRR = 1.06, 95% CI = 1.02\u20131.11), hypertension (IRR = 1.06, 95% CI = 1.02\u20131.11), heart disease (IRR = 1.06, 95% CI = 1.01\u20131.12), and lung disease (IRR = 1.14, 95% CI = 1.07\u20131.23) were associated with higher ADL-IADL scores among women, while there were no significant associations among men. Conclusion: The findings suggest potential for anti-inflammatory management among older women and optimal glycemic control among older men with these particular multimorbidity combinations as focus for therapeutic\/preventive options for maintaining functional health. <\/jats:p>","DOI":"10.1159\/000528648","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T22:00:26Z","timestamp":1677708026000},"page":"826-838","source":"Crossref","is-referenced-by-count":25,"title":["Multimorbidity and Functional Disability among Older Adults: The Role of Inflammation and Glycemic Status \u2013 An Observational Longitudinal 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