{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:18:08Z","timestamp":1789010288012,"version":"build-2803163510"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2023]]},"abstract":"<b><i>Introduction:<\/i><\/b> Copeptin, co-secreted with arginine vasopressin, is regulated by osmotic and volume stimuli but also responds to intravenous arginine and insulin-induced hypoglycemia. The serum copeptin response to the latter agents has been studied in adults but only to a limited extent in children. The objective of this study was to describe the copeptin response to combined arginine and insulin in children with normal posterior pituitary function. <b><i>Methods:<\/i><\/b> We conducted a prospective, single-arm assessment of serum copeptin concentrations in children (age 7\u201316 years, <i>n<\/i> = 38) undergoing growth hormone stimulation testing with an arginine-insulin tolerance test (AITT) for short stature or growth deceleration in a tertiary referral center. After overnight fasting, arginine (500 mg\/kg) was administered between 0 and 30 min intravenously (IV) followed by insulin (0.1 units\/kg IV) at 60 min. Copeptin serum concentrations were measured at baseline (0 min), at the post-arginine peak (60 min), and at the post-insulin peak (90 min; 30 min post-insulin), respectively. The main outcome was the peak copeptin concentration. <b><i>Results:<\/i><\/b> Mean \u00b1 SD copeptin concentrations increased from 9.9 \u00b1 5.0 pmol\/L at 0 min to 13.2 \u00b1 5.8 pmol\/L at 60 min (<i>p<\/i> &#x3c; 0.0001 vs. 0 min) and 27.7 \u00b1 14.2 pmol\/L at 90 min (<i>p<\/i> &#x3c; 0.0001 vs. 0 and 60 min). There was no significant correlation between copeptin concentrations and age, BMI, pubertal status, cortisol, growth hormone, or glucose concentrations. <b><i>Discussion\/Conclusion:<\/i><\/b> Arginine and insulin appear to have an additive and consistent effect resulting in significant stimulation of copeptin secretion in children. The AITT may be a useful tool to evaluate for normal posterior pituitary function in this age-group, with potential implications for the evaluation of polyuria-polydipsia syndrome. <\/jats:p>","DOI":"10.1159\/000528661","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T22:00:31Z","timestamp":1670968831000},"page":"395-403","source":"Crossref","is-referenced-by-count":11,"title":["Combined Arginine and Insulin Stimulation Elicits a Robust and Consistent Copeptin Response in Short Children"],"prefix":"10.1159","volume":"96","author":[{"given":"Christine A.","family":"March","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Sastry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"McPhaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Garibaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2499"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318033e5da"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.1.98"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.11.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2295"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0163"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803760"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31255-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2046"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14620"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03777-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-020-01076-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12608"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1994.1014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02314"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-0115(96)00098-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350543"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0130313"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00469.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72919"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350005"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb00923.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1110145"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13583"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/96\/4\/395\/3992518\/000528661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/96\/4\/395\/3992518\/000528661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:05:07Z","timestamp":1745420707000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000528661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,8,28]]},"published-print":{"date-parts":[[2023,8,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000528661","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}