{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:38:48Z","timestamp":1768808328809,"version":"3.49.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Nephrol Dial"],"abstract":"<jats:p>A 68-year-old man with a medical history of hypertension was admitted to the emergency department for diffuse abdominal pain preceded by bloody diarrhea. Upon admission, neurological examination was normal, but he suddenly developed a left-sided hemiparesis. After a normal brain computed tomography, intravenous thrombolysis was administered for a suspicion of ischemic stroke. In the first laboratory investigations, hemoglobin was 16.9 g\/dL, platelets 121 \u00d7 109\/L (150\u2013450), and serum creatinine 1.17 mg\/dL. By the second hospital day, the platelet level dropped to 79 \u00d7 109\/L, with haptoglobin at 0.12 g\/L, 3% schistocytes, and normal ADAMTS13 activity (57%). Serum creatinine increased to 1.84 mg\/dL with oliguria. The suspicion of thrombotic microangiopathy was supported by the identification of Shiga toxin genes stx1 and stx2 on a rectal swab and the isolation of an eaeA-negative Shiga toxin-producing E. coli O113:H4. The patient presented a generalized tonic-clonic seizure, and orotracheal intubation was required for decreased consciousness. Plasma exchange therapy was started, and eculizumab was given 6 days after symptoms onset. Brain magnetic resonance imaging (MRI) on day 13 showed symmetric hyperintensities within basal ganglia that disappeared on a second MRI on day 37. At 2-month follow-up, the patient had made a complete neurological and renal recovery and eculizumab therapy was stopped. <\/jats:p>","DOI":"10.1159\/000528893","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T22:03:25Z","timestamp":1674857005000},"page":"7-14","source":"Crossref","is-referenced-by-count":4,"title":["Severe Neurological Involvement in an Adult with Shiga Toxin-Producing Escherichia coli-Hemolytic Uremic Syndrome Treated with Eculizumab"],"prefix":"10.1159","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-3988","authenticated-orcid":false,"given":"Pauline","family":"Vanesse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3944-0436","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Georgery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-0100","authenticated-orcid":false,"given":"Thierry","family":"Duprez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Gerard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Collienne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Verroken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-5546","authenticated-orcid":false,"given":"Florence","family":"Cromb\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-1989","authenticated-orcid":false,"given":"Johann","family":"Morelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-3352","authenticated-orcid":false,"given":"Philippe","family":"Hantson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.09.011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02012739"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3336"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws090"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826d5f26"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-013-0231-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7010015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1100859"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001000"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.hkjn.2014.07.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/2324709617741144"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4565"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2012.1257"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.080361"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2004.12.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1086\/591911"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02730409"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-309161"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900151"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.11.009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61253-1"}],"container-title":["Case Reports in Nephrology and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cnd\/article-pdf\/13\/1\/7\/4081944\/000528893.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cnd\/article-pdf\/13\/1\/7\/4081944\/000528893.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:07:42Z","timestamp":1745420862000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000528893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000528893","archive":["Portico"],"relation":{},"ISSN":["2296-9705"],"issn-type":[{"value":"2296-9705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]}}}