{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:22:20Z","timestamp":1781767340518,"version":"3.54.5"},"reference-count":25,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Small intestinal bacterial overgrowth (SIBO) is associated with diarrhea-predominant irritable bowel syndrome (IBS-D). Probiotics like Saccharomyces boulardii CNCM I-745 (Sb) may be efficacious in balancing the microbiota. This randomized open label study assessed the effect of Sb in patients with bacterial overgrowth associated with IBS-D and its impact on the intestinal microbiota. Methods: Patients were randomized to receive Sb + dietary advice (Sb + DA) or dietary advice (DA) only for 15 days. SIBO was assessed by the lactulose hydrogen breath test (LHBT). Symptoms were assessed with the IBS Symptom Severity Scale (IBS-SSS) and stool consistency with the Bristol Stool Form Scale. Microbiota and mycobiota were analyzed by 16S rDNA and ITS2. Results: 54 patients were included, among whom 48 (27 Sb + DA, 21 DA) were evaluated. Decrease of hydrogen excretion was slightly higher in Sb + DA group, 41% versus 29% in DA group, and IBS-SSS total score were reduced by \u2212134 and \u221293, respectively. The proportion of patients with diarrhea was lower in the Sb + DA group than in the DA group (25.9% compared to 47.6%). Bacterial and fungal microbiota showed that Sb treatment was associated with several modifications. Interestingly, F. prausnitzii was more abundant in Sb-treated patients with marked clinical improvement. The safety of S. boulardii CNCM I-745 was excellent. Conclusions: In patients with SIBO, S. boulardii CNCM I-745 associated with dietary advice reduced bacterial overgrowth and improved digestive symptoms while restoring the intestinal microbiota. The increased abundance of F. prausnitzii coupled with symptom improvement merits further research. <\/jats:p>","DOI":"10.1159\/000528954","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T22:00:32Z","timestamp":1673474432000},"page":"798-809","source":"Crossref","is-referenced-by-count":30,"title":["Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study"],"prefix":"10.1159","volume":"41","author":[{"given":"Luis Maria","family":"Bustos Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-1659","authenticated-orcid":false,"given":"Juan Sebasti\u00e1n","family":"Lasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301501"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01891.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05007.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.54"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01926.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302167"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00286"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40795.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.46"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1004409"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13746"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05830-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000094"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.055"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318204593e"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S85574"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.06.011"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00281"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123720"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00468"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ddi\/article-pdf\/41\/5\/798\/3995613\/000528954.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ddi\/article-pdf\/41\/5\/798\/3995613\/000528954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:08:36Z","timestamp":1745420916000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000528954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,9,4]]},"published-print":{"date-parts":[[2023,9,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000528954","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}