{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:17:04Z","timestamp":1762377424150,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: The aim of this study was to investigate the effects and mechanism of deleted in malignant brain tumors 1 (DMBT1) protein on the mouse model of nasal polyps. Methods: The mouse model of nasal polyps was induced by intranasal drip intervention of lipopolysaccharide (LPS) 3 times a week for 12 weeks. A total of 42 mice were randomly divided into blank group, LPS group, and LPS+DMBT1 group. DMBT1 protein was applied by intranasal drip intervention in each nostril after LPS. After 12 weeks, 5 mice in each group were randomly picked for the mouse olfactory disorder experiment, 3 mice were randomly picked for histopathological observation of nasal mucosa, 3 mice for olfactory marker protein (OMP) immunofluorescence analysis and the last 3 mice were grabbed for nasal lavage, and the levels of cytokines interleukin (IL)-4, IL-5, IL-13, and phosphatidylinositide 3-kinases (PI3K) in the nasal lavage fluid were detected by enzyme-linked immunosorbent assay (ELISA). Results: Compared with the blank group, mice in LPS group had olfactory dysfunction, the level of OMP was significantly reduced, the nasal mucosa was swollen, discontinuous, and contained a large number of inflammatory cells. The levels of IL-4, IL-5, IL-13, and PI3K in the nasal lavage fluid were significantly increased in LPS group (p &amp;lt; 0.01). Compared with the LPS group, the number of mice with olfactory dysfunction in the LPS+DMBT1 group was less, the infiltration of inflammatory cells was reduced, the OMP-positive cells were significantly increased, and the IL-4, IL-5, IL-13, and PI3K in the nasal lavage fluid were significantly increased, p &amp;lt; 0.01. Conclusions: DMBT1 protein alleviates the nasal airway inflammatory response in the mouse nasal polyp model, and the mechanism may be through the PI3K-AKT signaling pathway. <\/jats:p>","DOI":"10.1159\/000529172","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T13:02:50Z","timestamp":1691413370000},"page":"808-813","source":"Crossref","is-referenced-by-count":3,"title":["DMBT1 Alleviates Nasal Airway Inflammatory Response in the LPS-Induced Nasal Polyp Model"],"prefix":"10.1159","volume":"184","author":[{"given":"Xiaoqing","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1713"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1369\/0022155420927109"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04159.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0027-x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064441"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109675"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.02.028"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.05.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ahg.12230"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.13201\/j.issn.1001-1781.2016.17.009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-15-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3386"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01861"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3444"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20175991"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000441"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.08.127"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/doi\/10.1159\/000529172\/3981015\/000529172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/doi\/10.1159\/000529172\/3981015\/000529172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:11:04Z","timestamp":1745421064000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000529172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":18,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8,7]]},"published-print":{"date-parts":[[2023,8,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000529172","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2023]]}}}