{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:45:43Z","timestamp":1787064343022,"version":"build-2736575974"},"reference-count":14,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>Herein, we report a case of bilateral simultaneous central retinal vein occlusion (CRVO) secondary to coronavirus disease 2019 (COVID-19). A 48-year-old man, with hypertension, type 2 diabetes mellitus, and stage 4 chronic kidney disease, diagnosed with COVID-19 1 month ago presented to the ophthalmology department with blurred vision in both eyes for 2 weeks. Ocular examination revealed a classic clinical presentation of CRVO in both eyes. Optical coherence tomography revealed increased central macular thickness with intraretinal and subretinal fluid in both eyes. Laboratory data revealed elevated D-dimer and C-reactive protein (CRP) levels. The levels of other hypercoagulability markers were normal. The patient received intravitreal anti-vascular endothelial growth factor therapy in both eyes, followed by regular follow-up every month until complete resolution of symptoms and gradual improvement of the retinal vascular appearance. COVID-19 can cause a variety of coagulation abnormalities and thromboembolic complications such as bilateral simultaneous CRVO. Clinicians and patients should be aware of ocular symptoms and presentations that are probably associated with COVID-19.<\/jats:p>","DOI":"10.1159\/000529298","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:15:46Z","timestamp":1697649346000},"page":"56-61","source":"Crossref","is-referenced-by-count":8,"title":["Bilateral Simultaneous Central Retinal Vein Occlusion Secondary to COVID-19: A Case Report"],"prefix":"10.1159","author":[{"given":"Chien-Hung","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2020.03.019"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30183-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000308"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.4.513"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120960333"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006000"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03909.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0474-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2009787"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153233"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/11206721211001019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102898"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.927691"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/joco.joco_277_21"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cop\/article-pdf\/14\/1\/56\/3980639\/000529298.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cop\/article-pdf\/14\/1\/56\/3980639\/000529298.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:12:15Z","timestamp":1745406735000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000529298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1159\/000529298","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.22093667","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]}}}