{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:14:43Z","timestamp":1756383283678,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: The aim of this study was to compare the changes in serum concentrations of vascular endothelial growth factor (VEGF)-A and B after intravitreal injection of ranibizumab (IVR) or conbercept (IVC) for retinopathy of prematurity (ROP). Methods: In this prospective study, infants with type 1 ROP in both eyes were recruited in our hospital from September 2021 to February 2022, randomly assigned to the ranibizumab and conbercept groups and administered IVR or IVC (0.25 mg\/0.025 mL). Blood samples were collected before the operation and 1 and 4 weeks after the operation to measure the concentrations of serum VEGF-A and B. Results: A total of 20 ROP infants were randomly assigned to the ranibizumab (n = 10) and conbercept groups (n = 10). In the ranibizumab group, the serum VEGF-A concentrations before operation and 1 and 4 weeks after the operation were 73.55 \u00b1 40.78, 11.47 \u00b1 7.00, and 75.36 \u00b1 30.87 pg\/mL, respectively (p &amp;lt; 0.01). Least Significant Difference (LSD) pairwise comparison did not show any significant difference in the groups between 4 weeks postoperatively and preoperatively (p &amp;gt; 0.05). In the conbercept group, the serum VEGF-A concentrations before operation and 1 and 4 weeks after the operation were 86.69 \u00b1 55.06, 14.68 \u00b1 10.11, and 43.55 \u00b1 57.92 pg\/mL, respectively (p &amp;lt; 0.01). LSD comparison showed significant differences between 1 week and 4 weeks postoperatively and preoperatively (p &amp;lt; 0.05), but no significant differences were observed between 1 and 4 weeks postoperatively (p &amp;gt; 0.05). Regarding serum VEGF-B concentrations before the operation and 1 and 4 weeks after the operation, no significant differences were detected in the ranibizumab group (p &amp;gt; 0.05), but significant differences were observed in the conbercept group (7.26 \u00b1 2.34, 3.09 \u00b1 2.41, and 4.55 \u00b1 3.37 ng\/mL, respectively; p &amp;lt; 0.01). LSD showed significant differences between 1 or 4 weeks postoperatively and preoperatively (p &amp;lt; 0.05), but no significant difference was detected between 1 and 4 weeks postoperatively (p &amp;gt; 0.05). Conclusions: Serum VEGF-A levels in infants with ROP were suppressed after IVR or IVC but returned to preoperative levels at 4 weeks after IVR and remained lower than the preoperative levels at 4 weeks after IVC. Serum VEGF-B was not affected by IVR but was suppressed by IVC for 4 weeks. <\/jats:p>","DOI":"10.1159\/000529393","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T22:01:13Z","timestamp":1674856873000},"page":"81-89","source":"Crossref","is-referenced-by-count":3,"title":["Changes in Serum Concentrations of Vascular Endothelial Growth Factors-A and B after Intravitreal Injection of Ranibizumab and Conbercept for Retinopathy of Prematurity"],"prefix":"10.1159","volume":"246","author":[{"given":"Haitao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhua","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.18043\/ncm.78.2.124"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.22608\/APO.201837"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.09.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1007374"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.22608\/APO.2017436"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15842"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001209"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/380435a0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.03.018"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14460"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311662"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108083"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4161\/cam.3.4.9459"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.031"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.01.020"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.5373"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/JOCO.JOCO_78_20"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.8.43"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2985161"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21813"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69684-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-319131"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3878-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28987-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2020.11.020"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/oph\/article-pdf\/246\/2\/81\/3958453\/000529393.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/oph\/article-pdf\/246\/2\/81\/3958453\/000529393.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:13:15Z","timestamp":1745421195000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000529393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,7,14]]},"published-print":{"date-parts":[[2023,7,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000529393","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"type":"print","value":"0030-3755"},{"type":"electronic","value":"1423-0267"}],"subject":[],"published":{"date-parts":[[2023]]}}}