{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:34:57Z","timestamp":1770226497832,"version":"3.49.0"},"reference-count":13,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Primary pleural angiosarcoma (PPA) is a rare and clinically fatal pleural tumor originating from vascular endothelial cells. Herein, we presented the case of a 73-year-old man who was referred to our emergency room with complaints of right chest and back pain for a few days. Chest computed tomography revealed massive pleural effusion and a large mass in the right chest cavity. Thoracoscopic examination demonstrated a large hemorrhagic tumor on the parietal pleura whose pathological analysis indicated PPA. The patient received immunotherapy combined with nivolumab and ipilimumab. A cycle of nivolumab and ipilimumab improved his hemorrhagic anemia and reduced the pleural effusion and tumor size. This treatment outcome suggests that nivolumab and ipilimumab comprise a vital treatment option for PPA. <\/jats:p>","DOI":"10.1159\/000529447","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T22:00:43Z","timestamp":1676671243000},"page":"81-87","source":"Crossref","is-referenced-by-count":2,"title":["Primary Pleural Angiosarcoma Treated with Nivolumab and Ipilimumab: A Case Report"],"prefix":"10.1159","author":[{"given":"Mikako","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1912-2406","authenticated-orcid":false,"given":"Kento","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4492-9327","authenticated-orcid":false,"given":"Kazuhiro","family":"Usui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70023-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028785"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(19991115)86:10%3c2034::aid-cncr21%3e3.0.co;2-p"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22822"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.037"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.3146"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2016.01005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002990"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0263-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0689-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3271"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027132"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/20.037"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/81\/4013056\/000529447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/81\/4013056\/000529447.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:13:31Z","timestamp":1745421211000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000529447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1159\/000529447","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.22093631","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]}}}