{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:25:36Z","timestamp":1770290736293,"version":"3.49.0"},"reference-count":7,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>When primary acquired melanosis (PAM) with atypia affects the tarsal conjunctiva, a radical surgery can be mutilating, requiring reconstructive surgery of the eyelid. Topical chemotherapy associated to local cryotherapy may be an alternative. A 64-year-old Caucasian female presented with diffuse PAM of the right eye involving the inferior tarsal conjunctiva, fornix, and inferotemporal bulbar conjunctiva. Histological study showed a PAM with atypia (C-MIN 5). Given the extent of the lesion and its location, a wide mutilating excision was ruled out. Topical interferon alpha 2b (IFN-\u03b12b) treatment (1,000,000 IU\/mL, 4 times a day) was administered during 10 weeks. However, the regression was very slow. Then local cryotherapy was proposed (8 s at \u221280\u00b0C per application) to the entire pigmented lesion. This afforded progressive depigmentation, which was completed 2 months later. No recurrence of the lesion has been noted during 3 years of follow-up. The combination of the two procedures reduces IFN-\u03b12b eyedrop administration time, enhancing patient compliance. The combination may eradicate the tumor without compromising ocular cosmesis. <\/jats:p>","DOI":"10.1159\/000529667","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:16:01Z","timestamp":1697663761000},"page":"104-107","source":"Crossref","is-referenced-by-count":3,"title":["Cryotherapy after Topical Interferon Alpha 2b to Treat Conjunctival Primary Acquired Melanosis"],"prefix":"10.1159","author":[{"given":"Valent\u00edn","family":"Huerva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felip","family":"Vilardell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Cid-Bertomeu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2003.10.008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000522195"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2013.01.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.06.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2015.1115880"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2022.03.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000277"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cop\/article-pdf\/14\/1\/104\/3980710\/000529667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cop\/article-pdf\/14\/1\/104\/3980710\/000529667.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:15:46Z","timestamp":1745421346000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000529667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":7,"URL":"https:\/\/doi.org\/10.1159\/000529667","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.22283875","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]}}}