{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:21:52Z","timestamp":1787714512232,"version":"build-2784847793"},"reference-count":11,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Gonadotrophin-releasing hormone agonists (GnRHas) are used for puberty suppression in central precocious puberty (CPP) and gender dysphoria (GD). Guidelines on biochemical monitoring are not defined. Objectives: The aim of this study was to evaluate the utility of biochemical monitoring of GnRHa therapy in patients with CPP or GD. Methods: This is a retrospective chart review of patients 18 years or younger who received GnRHa therapy from January 1, 2018, to March 20, 2021. Results: A total of 103 patients were evaluated, 43 with CPP and 60 with GD. Using thresholds of basal luteinizing hormone (LH) &amp;lt;2 IU\/L and stimulated LH &amp;lt;4 IU\/L, biochemical pubertal suppression occurred in all but 2 patients. Basal LH frequently remained above prepubertal range. Conclusions: Laboratory assessment for puberty suppression on GnRHa therapy may be unnecessary in CPP and GD patients monitored with physical exams. <\/jats:p>","DOI":"10.1159\/000529733","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T22:06:36Z","timestamp":1676498796000},"page":"523-526","source":"Crossref","is-referenced-by-count":5,"title":["Review of Implant Gonadotrophin-Releasing Hormone Agonist Use: Experience in a Single Academic Center"],"prefix":"10.1159","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-8079","authenticated-orcid":false,"given":"Jennifer","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tandy","family":"Aye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01658"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01943.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/26895269.2022.2100644"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1919"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2479"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.038"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2013-20"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1569"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70255-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.e30"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/96\/5\/523\/4014875\/000529733.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/96\/5\/523\/4014875\/000529733.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:16:29Z","timestamp":1745421389000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000529733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,6]]},"published-print":{"date-parts":[[2023,10,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000529733","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}