{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T20:45:30Z","timestamp":1763585130841,"version":"3.40.5"},"reference-count":49,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: We aim to correlate pre- and postnatal data regarding the cleft type and surgical prognostic factors associated to orofacial clefts. Methods: Retrospective study concerning all cases of orofacial cleft evaluated prenatally (US+\/\u2212MRI) between 2015 and 2020 with available postnatal outcomes. We compared prenatal imaging (cleft type and surgical prognostic factors) with postnatal findings. Results: 48 fetuses were included. Median gestational age at first US\/MRI examination: 29+2 WG and 31+6 WG, respectively. The prenatal diagnosis was in accordance with postnatal findings with regard to the cleft type in 88% of the cases (n = 42\/48) for US and\/or MRI, 84% (n = 38\/45) for US only, and 90% (n = 37\/41) for MRI only. The nasal septum deviation and nostril collapse were underestimated by prenatal US in 48% (n = 12\/25) and 44% (n = 11\/25) of cases, respectively (Cohen\u2019s kappa of 0.22 and 0.32, respectively). Pre- and postnatal examinations were in accordance with 75% of cases (n = 8) regarding evaluation of anteroposterior maxillary shift in case of unilateral alveolar cleft and in 90% and 80% of cases (n = 10) regarding the degree of protrusion\/deviation of the premaxillary protrusion in case of bilateral cleft, respectively. Conclusion: Prenatal imaging can accurately assess the type of orofacial cleft and evaluate maxillary shift and deviation of the premaxilla. It underestimates the nose deformity. <\/jats:p>","DOI":"10.1159\/000529821","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T22:00:27Z","timestamp":1677621627000},"page":"70-83","source":"Crossref","is-referenced-by-count":2,"title":["Imaging Factors Affecting Prenatal Counseling in Orofacial Clefts"],"prefix":"10.1159","volume":"50","author":[{"given":"Anne-Laure","family":"Hermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Soupre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Vande 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