{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:43Z","timestamp":1747193623576,"version":"3.40.5"},"reference-count":36,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lifestyle Genomics"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Genes encoding catechol-O-methyl-transferase (COMT) and adenosine A2A receptor (ADORA2A) have been shown to influence cognitive performances and responses to caffeine intake during prolonged wakefulness. The rs4680 single-nucleotide polymorphism (SNP) of COMT differentiates on memory score and circulating levels of the neurotrophic factor IGF-1. This study aimed to determine the kinetics of IGF-1, testosterone, and cortisol concentrations during prolonged wakefulness under caffeine or placebo intake in 37 healthy participants, and to analyze whether the responses are dependent on COMT rs4680 or ADORA2A rs5751876 SNPs. Methods: In caffeine (2.5 mg\/kg, twice over 24 h) or placebo-controlled condition, blood sampling was performed at 1 h (08:00, baseline), 11 h, 13 h, 25 h (08:00 next day), 35 h, and 37 h of prolonged wakefulness, and at 08:00 after one night of recovery sleep, to assess hormonal concentrations. Genotyping was performed on blood cells. Results: Results indicated a significant increase in IGF-1 levels after 25, 35, and 37 h of prolonged wakefulness in the placebo condition, in subjects carrying the homozygous COMT A\/A genotype only (expressed in absolute values [\u00b1SEM]: 118 \u00b1 8, 121 \u00b1 10, and 121 \u00b1 10 vs. 105 \u00b1 7 ng\/mL for A\/A, 127 \u00b1 11, 128 \u00b1 12, and 129 \u00b1 13 vs. 120 \u00b1 11 ng\/mL for G\/G, and 106 \u00b1 9, 110 \u00b1 10, and 106 \u00b1 10 vs. 101 \u00b1 8 ng\/mL for G\/A, after 25, 35, and 37 h of wakefulness versus 1 h; p &amp;lt; 0.05, condition X time X SNP). Acute caffeine intake exerted a COMT genotype-dependent reducing effect on IGF-1 kinetic response (104 \u00b1 26, 107 \u00b1 27, and 106 \u00b1 26 vs. 100 \u00b1 25 ng\/mL for A\/A genotype, at 25, 35, and 37 h of wakefulness vs. 1 h; p &amp;lt; 0.05 condition X time X SNP), plus on resting levels after overnight recovery (102 \u00b1 5 vs. 113 \u00b1 6 ng\/mL) (p &amp;lt; 0.05, condition X SNP). Testosterone and cortisol concentrations decreased during wakefulness, and caffeine alleviated the testosterone reduction, unrelated to the COMT polymorphism. No significant main effect of the ADORA2A SNP was shown regardless of hormonal responses. Conclusion: Our results indicated that the COMT polymorphism interaction is important in determining the IGF-1 neurotrophic response to sleep deprivation with caffeine intake (NCT03859882). <\/jats:p>","DOI":"10.1159\/000529897","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T21:04:16Z","timestamp":1689887056000},"page":"113-123","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Acute Caffeine Intake on Insulin-Like Growth Factor-1 Responses to Total Sleep Deprivation: Interactions with COMT Polymorphism \u2013 A Randomized, Crossover Study"],"prefix":"10.1159","author":[{"given":"Catherine","family":"Drogou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-2319","authenticated-orcid":false,"given":"Fabien","family":"Sauvet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9gane","family":"Erblang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Leger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounir","family":"Chennaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Gomez-Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Investigators 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