{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:27:31Z","timestamp":1783434451487,"version":"3.54.6"},"reference-count":16,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Chronic myelogenous leukemia at blast crisis with a T-cell phenotype (T-ALL CML-BC) at diagnosis, without any prior history of CML is extremely rare. After the introduction of tyrosine kinase inhibitors (TKIs), CML patients have a median survival comparable to general population and accelerated\/blast crisis are rarely encountered. Most CML patients (80%) transform into acute myeloid leukemia and the rest into B-ALL. Anecdotal cases of Ph+ T-ALL, either de novo or in the context of CML-BC have been reported. Left shift in the blood, the presence of splenomegaly\/extramedullary infiltration and the occurrence of BCR::ABL1 rearrangement in both the blastic population, as well as in the myeloid cell compartment are key points in differentiating de novo Ph+ T-ALL from T-ALL CML-BC. The latter is a rare entity, characterized by extramedullary disease, p210 transcript and clonal evolution. Lack of preceding CML does not rule out the diagnosis of T-ALL CML-BC. Prompt TKI treatment with ALL-directed therapy followed by allogeneic stem cell transplantation may offer long-term survival in this otherwise poor prognosis entity. In this paper, we describe a patient with T-ALL CML-BC at presentation, still alive 51 months after diagnosis and we offer a review of the literature on this rare subject. All clinical and laboratory features are provided in order to distinguish de novo Ph+ T-ALL from T-ALL CML-BC, underscoring the prognostic and therapeutic significance of such a differentiation. <\/jats:p>","DOI":"10.1159\/000529911","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T21:01:27Z","timestamp":1691614887000},"page":"530-537","source":"Crossref","is-referenced-by-count":1,"title":["A Case Report of Chronic Myelogenous Leukemia Presenting as Blastic Crisis with a T-Cell Acute Lymphoblastic Leukemia Phenotype: Awareness of a Rare Entity"],"prefix":"10.1159","volume":"146","author":[{"given":"Maria","family":"Efstathopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Zoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-4657","authenticated-orcid":false,"given":"Marina P.","family":"Siakantaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Koumbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia-Faidra","family":"Triantafyllou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerassimos","family":"Tsourouflis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-0192","authenticated-orcid":false,"given":"Eleftheria","family":"Lakiotaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-1853","authenticated-orcid":false,"given":"Theodoros P.","family":"Vassilakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria K.","family":"Angelopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0776-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24579"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.66.2866"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609324"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01111-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000084448"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.2.168"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-001-0422-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1309\/GTGTEQAFMV30W753"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000348681"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/304359"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7276128"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23241"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.531"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.298"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309047892"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/6\/530\/4118388\/000529911.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/6\/530\/4118388\/000529911.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:18:22Z","timestamp":1745421502000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000529911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,22]]},"published-print":{"date-parts":[[2023,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000529911","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}