{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:52:13Z","timestamp":1778770333601,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Acute tonsillopharyngitis or sore throat is an initial sign of viral respiratory tract infection (RTI) and an optimal indicator for early antiviral and anti-inflammatory intervention. Both of these actions have been attributed to Echinacea purpurea and Salvia officinalis. Methods: 74 patients (age 13\u201369 years) with acute sore throat symptoms (&amp;lt;48 h) were treated with five Echinacea\/Salvia lozenges per day (4,000 mg Echinacea purpurea extract [Echinaforce\u00ae] and 1,893 mg Salvia officinalis extract [A. Vogel AG, Switzerland] daily) for 4 days. Symptom intensities were recorded in a diary and oropharyngeal swab samples collected for virus detection and quantification via RT-qPCR. Results: The treatment was exceptionally well tolerated, no complicated RTI developed, and no antibiotic treatment was required. A single lozenge reduced throat pain by 48% (p &amp;lt; 0.001) and tonsillopharyngitis symptoms by 34% (p &amp;lt; 0.001). Eighteen patients tested virus positive at inclusion. Viral loads in these patients was reduced by 62% (p &amp;lt; 0.03) after intake of a single lozenge and by 96% (p &amp;lt; 0.02) after 4 days of treatment compared to pre-treatment. Conclusions: Echinacea\/Salvia lozenges represent a valuable and safe option for the early treatment of acute sore throats capable to alleviate symptoms and contribute to reducing viral loads in the throat. <\/jats:p>","DOI":"10.1159\/000530017","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T22:00:36Z","timestamp":1678312836000},"page":"299-306","source":"Crossref","is-referenced-by-count":6,"title":["Reduction of Viral Load in Patients with Acute Sore Throats: Results from an Observational Clinical Trial with Echinacea\/Salvia Lozenges"],"prefix":"10.1159","volume":"30","author":[{"given":"Ramon","family":"Weishaupt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-799X","authenticated-orcid":false,"given":"Alexandar","family":"Buchkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Kolev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-9650","authenticated-orcid":false,"given":"Peter","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Schoop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02722930"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.13019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70270-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.2.539-542.1998"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8561(22)00434-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101183440308"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.21.2531"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12162-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/841315"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2015.04.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-012-0166-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-015-0194-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-020-01401-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-197"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.04.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.10.022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-021-00499-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.09.078"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1021\/jf0715323"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783x-14-9-406"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3212-3218.2004"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-124"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0281-8"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/02813430600638227"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-425085\/v1"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/30\/4\/299\/3999289\/000530017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/30\/4\/299\/3999289\/000530017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:19:29Z","timestamp":1745421569000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,9,12]]},"published-print":{"date-parts":[[2023,9,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000530017","archive":["Portico"],"relation":{},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"value":"2504-2092","type":"print"},{"value":"2504-2106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}