{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:51:30Z","timestamp":1787755890361,"version":"build-2784847793"},"reference-count":50,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: High-dose chemotherapy (HDCT) followed by autologous blood stem-cell transplantation (ABSCT) remains the standard consolidation therapy for newly diagnosed eligible multiple myeloma (MM) patients. As a prerequisite, peripheral blood stem cells (PBSCs) must be mobilized and collected by leukapheresis (LP). Many factors can hamper PBSC mobilization\/collection. Here, we provide a comprehensive multiparametric assessment of PBSC mobilization\/collection outcome parameters in a large cohort. Methods: In total, 790 MM patients (471 [60%] male, 319 [40%] female) who underwent PBSC mobilization\/collection during first-line treatment were included. Evaluated PBSC mobilization\/collection outcome parameters included the prolongation of PBSC mobilization, plerixafor administration, number of LP sessions, and overall PBSC collection goal\/result. Results: 741 (94%) patients received cyclophosphamide\/adriamycin\/dexamethasone (CAD) and granulocyte-colony-stimulating factor (G-CSF) mobilization. Plerixafor was administered in 80 (10%) patients. 489 (62%) patients started LP without delay. 530 (67%) patients reached the PBSC collection goal at the first LP session. The mean overall PBSC collection result was 10.3 (standard deviation [SD] 4.4) \u00d7 106 CD34+ cells\/kg. In a multiparametric analysis, variables negatively associated with PBSC mobilization\/collection outcomes were female gender, age &amp;gt;60 years, an advanced ISS stage, and local radiation pre-\/during induction, but not remission status postinduction. Notably, the identified risk factors contributed differently to each PBSC mobilization\/collection outcome parameter. In this context, compared to all other induction regimens, lenalidomide-based induction with\/without antibodies negatively affected only the number of LP sessions required to reach the collection goal, but no other PBSC mobilization\/collection outcome parameters. In contrast, the probability of reaching a high collection goal of \u22656 \u00d7 106 CD34+ cells\/kg body weight was higher after lenalidomide-based induction compared to VCD\/PAD or VAD \u2013 taking into account \u2013 that a higher G-SCF dosage was given in approximately one-third of patients receiving lenalidomide-based induction with\/without antibodies. Conclusion: Considering the identified risk factors in the clinical setting can contribute to optimized PBSC mobilization\/collection. Moreover, our study demonstrates the necessity for a differentiated evaluation of PBSC mobilization\/collection outcome parameters.<\/jats:p>","DOI":"10.1159\/000530056","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T07:53:56Z","timestamp":1697097236000},"page":"382-395","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Clinical Parameters and Induction Regimens on Peripheral Blood Stem-Cell Mobilization and Collection in Multiple Myeloma 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