{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:51:18Z","timestamp":1789275078608,"version":"build-2803163510"},"reference-count":35,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Tau protein accumulation in the brain is thought to be one of the causes of progressive supranuclear palsy (PSP). The glymphatic system was discovered a decade ago as a waste drainage system in the brain that promotes the elimination of amyloid-beta and tau protein. We here evaluated the relationships between glymphatic system activity and regional brain volumes in PSP patients. Method: Subjects were 24 patients with PSP and 42 healthy participants who underwent diffusion tensor imaging (DTI). We computed the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index as a proxy of glymphatic system activity and estimated the relationships between the DTI-ALPS index and regional brain volume in PSP patients by whole-brain and region-of-interest analyses, including analyses of the midbrain and third and lateral ventricles. Results: The DTI-ALPS index was significantly lower in patients with PSP compared with healthy subjects. Further, there were significant correlations between the DTI-ALPS index and the regional brain volumes in the midbrain tegmentum, pons, right frontal lobe, and lateral ventricles in patients with PSP. Conclusions: Our data suggest that the DTI-ALPS index is a good biomarker for PSP and might be effective to distinguish PSP from other neurocognitive disorders. <\/jats:p>","DOI":"10.1159\/000530075","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T22:00:31Z","timestamp":1678744831000},"page":"177-183","source":"Crossref","is-referenced-by-count":11,"title":["Correlation between the Regional Brain Volume and Glymphatic System Activity in Progressive Supranuclear Palsy"],"prefix":"10.1159","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-0822","authenticated-orcid":false,"given":"Miho","family":"Ota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-2498","authenticated-orcid":false,"given":"Yoko","family":"Shigemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moto","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-5217","authenticated-orcid":false,"given":"Emiko","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02158-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.07.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00054.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1406-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00063"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1512-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.1.81"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.12.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.07.016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67677"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4370"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-017-0617-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-021-01187-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220534"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26516"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12837"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4034509"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.773951"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12091126"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191744"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26054"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.08.016"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.065"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6745-6"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14322"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2022.2052622"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19874790"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.11.009"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5675014"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-004-0326-9"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118257"}],"container-title":["Dementia 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