{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:46:25Z","timestamp":1772034385588,"version":"3.50.1"},"reference-count":56,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Myeloid differentiation protein 1 (MD1), a negative regulator of toll-like receptor 4 (TLR4), is widely expressed in the heart. Recent studies have shown that MD1 plays an important role in cardiac remodelling. However, the effects and potential mechanisms underlying MD1-mediated atrial remodelling in diabetic cardiomyopathy (DCM) remain unclear. Therefore, this study was designed to explore the role of MD1 in DCM-related atrial remodelling. Methods: MD1 knockout (MD1-KO) mice and wild-type (WT) littermates were injected with streptozotocin (STZ) to establish a diabetic mouse model. These mice were then used to evaluate MD1 expression and its effects on atrial remodelling in vivo. Results: MD1 expression was significantly decreased in STZ-induced diabetic mice. The loss of MD1 aggravated atrial fibrosis, inflammation, and apoptosis in DCM mice and promoted atrial remodelling. MD1-KO diabetic mice also showed higher susceptibility to atrial fibrillation (AF) and worse cardiac function. Mechanistically, the deletion of MD1 promoted the activation of the TLR4\/NF-\u03baB signalling pathway, resulting in atrial remodelling in DCM mice via increased p65 phosphorylation. Conclusions: The deletion of MD1 plays an important role in inflammatory and apoptotic atrial remodelling and increases susceptibility to AF in DCM mice, providing a new target for the preventive treatment of DCM-related atrial remodelling. <\/jats:p>","DOI":"10.1159\/000530081","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T21:24:05Z","timestamp":1687209845000},"page":"311-320","source":"Crossref","is-referenced-by-count":7,"title":["Loss of MD1 Promotes Inflammatory and Apoptotic Atrial Remodelling in Diabetic Cardiomyopathy by Activating the TLR4\/NF-\u03baB Signalling Pathway"],"prefix":"10.1159","volume":"108","author":[{"given":"Tonghuan","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-0926","authenticated-orcid":false,"given":"Jianye","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679597"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-013-9377-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.846519"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.241.19.2035"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.02.012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.686848"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039836"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.06.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29556"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.127"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1556946"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.01.021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02474-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2018.05.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.08.029"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.3.1348"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2106"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.09.020"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1179\/096805105X67300"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/srep41857"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.11.025"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2019.06.004"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4070-9"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4469-y"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4390-4"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0339-2"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114000"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.05.044"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-015-0863-4"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01957-4"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-018-0157-8"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20192384"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9667-2"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00528.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00135"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11291"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.019"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.107.754564"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00010.2012"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.255026"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0604-9"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu176"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.20.2471"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.744466"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000470"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.10.020"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.10.029"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.05.007"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000781"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq146"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.2"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.899"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12191"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.09.018"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pha\/article-pdf\/108\/4\/311\/3966691\/000530081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pha\/article-pdf\/108\/4\/311\/3966691\/000530081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:20:05Z","timestamp":1745421605000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,7,3]]},"published-print":{"date-parts":[[2023,7,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000530081","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.22501459","asserted-by":"subject"}]},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}