{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:32:09Z","timestamp":1792114329731,"version":"4.4.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Topical drugs are often used as first-line treatment for dermatological conditions. A within-person design may then be well adapted: it consists of randomizing lesions\/body sites rather than patients, which are then concomitantly treated by the different drugs compared, reducing inter-group variability and therefore requiring fewer patients than the classical parallel-group trial. Objectives: The aim of this review was to provide a methodological overview of within-person randomized trials (WP-RCTs) in dermatology. Methods: We searched for eligible trials published between 2017 and 2021 in MEDLINE, Embase, and Central in dermatology journals and the 6 highest-impact-factor general medical journals. Two authors selected publications and extracted data independently. Results: From 1,034 articles identified, we included 54 WP-RCTs, mainly for acne vulgaris, psoriasis, actinic keratosis, and atopic dermatitis. In most of the trials, patients had only 2 lesions\/body sites. In none of the trials, did we detect a potential carry-across effect (known to be the major methodological problem in WP-RCTs). Twelve studies reported a care provider applying the treatment, and in 26 studies, the patients themselves applied the treatment. Finally, we also highlight statistical issues for the statistical analysis: overall, 14 (26.9%) studies used a test for independent observations, thus ignoring the between-lesion correlation. Conclusion: Our systematic review highlights that despite the publication of the CONSORT checklist extension for WP-RCTs in 2017, this design is rarely used, and when it is, there are methodological and reporting concerns. <\/jats:p>","DOI":"10.1159\/000530149","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T21:00:37Z","timestamp":1680123637000},"page":"720-731","source":"Crossref","is-referenced-by-count":9,"title":["Design and Methodological Issues of Within-Person (Split-Body) Randomized Controlled Trials Evaluating a Topical Treatment: A Systematic Review"],"prefix":"10.1159","volume":"239","author":[{"given":"Sophie","family":"Leducq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Dugard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Allemang-Trivalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Giraudeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Maruani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13783"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.032"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.041"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.1130"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.296"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.1127"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.03.945"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10351.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.527"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.5.581"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2835"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13305"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.027"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.1610"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3767-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-48"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2000.009003165.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-009-0405-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu115"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1687"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09334-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085949"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.025"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01118.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3634"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/239\/5\/720\/4029724\/000530149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/239\/5\/720\/4029724\/000530149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:20:57Z","timestamp":1745421657000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,10]]},"published-print":{"date-parts":[[2023,10,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000530149","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.22352914","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}