{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:17:12Z","timestamp":1786573032138,"version":"build-2736575974"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Psoriasis is a chronic inflammatory skin disorder, affecting the trunk and extensor surfaces of the limbs and scalp predominantly. Worldwide prevalence ranges between 0.1 and 11.4%, and in India between 0.4 and 2.8%; this creates a serious health burden. Psoriasis remains a frequently encountered condition in homeopathy practice, but there is a dearth of conclusive efficacy data supporting its use. Methods: This 6-month, double-blind, randomized trial was conducted on 51 patients suffering from psoriasis at the National Institute of Homoeopathy, India. Patients were randomized to receive either individualized homeopathic medicines (IHMs; n = 25) in LM potencies or identical-looking placebos (n = 26). Psoriasis area and severity index (PASI; primary), psoriasis disability index (PDI), and dermatological life quality index (DLQI; secondary) were measured at baseline and every 2 months, up to 6 months. The intention-to-treat sample was analyzed using a two-way repeated measure analysis of variance. Results: Although intragroup changes were significant in both groups in the outcome measures, improvements were significantly higher in the IHMs group than in placebos in PASI scores after 6 months of intervention (F1, 49 = 10.448, p = 0.002). DLQI daily activity subscale scores also yielded similar significant results favoring IHMs against placebos after 6 months (F1, 49 = 5.480, p = 0.023). Improvement in PDI total (F1, 49 = 0.063, p = 0.803), DLQI total (F1, 49 = 1.371, p = 0.247), and all remaining subscales were higher in the IHMs group than placebos after 6 months, but nonsignificant statistically. Calcarea carbonica, Mercurius solubilis, Arsenicum album, and Petroleum were the most frequently prescribed medicines. Conclusions: IHMs exhibited better results than placebos in the treatment of psoriasis. Further research is warranted. <\/jats:p>","DOI":"10.1159\/000530180","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T21:00:27Z","timestamp":1691442027000},"page":"317-331","source":"Crossref","is-referenced-by-count":4,"title":["Individualized Homeopathic Medicines in the Treatment of Psoriasis Vulgaris: Double-Blind, Randomized, Placebo-Controlled Trial"],"prefix":"10.1159","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-7950","authenticated-orcid":false,"given":"Dharshna","family":"Balamurugan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintamani","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avaranjika","family":"Karuppusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Malathi","family":"Ambrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4706-9692","authenticated-orcid":false,"given":"Munmun","family":"Koley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhranil","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1296_17"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_113_21"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.585634"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2174\/187153012802002901"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03116.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2197"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.15406\/ijcam.2020.13.00496"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03562.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05019.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/jdds.jdds_38_19"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181d9d421"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2006.6352"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1743811"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18634"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021549"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/30\/4\/317\/3999303\/000530180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/30\/4\/317\/3999303\/000530180.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:21:24Z","timestamp":1745421684000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,9,12]]},"published-print":{"date-parts":[[2023,9,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000530180","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.23276315","asserted-by":"subject"}]},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"value":"2504-2092","type":"print"},{"value":"2504-2106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}