{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:19:33Z","timestamp":1790907573498,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Renal glycogen synthase kinase-3 beta (GSK3\u03b2) overactivity has been associated with a diverse range of kidney diseases. GSK3\u03b2 activity in urinary exfoliated cells was reported to predict the progression of diabetic kidney disease (DKD). We compared the prognostic value of urinary and intrarenal GSK3\u03b2 levels in DKD and nondiabetic chronic kidney disease (CKD). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We recruited 118 consecutive biopsy-proved DKD patients and 115 nondiabetic CKD patients. Their urinary and intrarenal GSK3\u03b2 levels were measured. They were then followed for dialysis-free survival and rate of renal function decline. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; DKD group had higher intrarenal and urinary GSK3\u03b2 levels than nondiabetic CKD (&lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.0001 for both), but their urinary GSK3\u03b2 mRNA levels were similar. Urinary p-GSK3\u03b2 level is statistically significantly correlated with the baseline estimated glomerular filtration rate (eGFR), but urinary GSK3\u03b2 level by ELISA, its mRNA level, the p-GSK3\u03b2 level, or the p-GSK3\u03b2\/GSK3\u03b2 ratio had no association with dialysis-free survival or the slope of eGFR decline. In contrast, the intrarenal pY216-GSK3\u03b2\/total GSK3\u03b2 ratio significantly correlated with the slope of eGFR decline (&lt;i&gt;r&lt;\/i&gt; = \u22120.335, &lt;i&gt;p&lt;\/i&gt; = 0.006) and remained an independent predictor after adjusting for other clinical factors. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Intrarenal and urinary GSK3\u03b2 levels were increased in DKD. The intrarenal pY216-GSK3\u03b2\/total GSK3\u03b2 ratio was associated with the rate of progression of DKD. The pathophysiological roles of GSK3\u03b2 in kidney diseases deserve further studies. <\/jats:p>","DOI":"10.1159\/000530210","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T22:00:40Z","timestamp":1679349640000},"page":"241-248","source":"Crossref","is-referenced-by-count":5,"title":["Intrarenal and Urinary Glycogen Synthase Kinase-3 Beta Levels in Diabetic and Nondiabetic Chronic Kidney Disease"],"prefix":"10.1159","volume":"48","author":[{"given":"Lingfeng","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-9611","authenticated-orcid":false,"given":"Jack Kit-Chung","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-7628","authenticated-orcid":false,"given":"Winston Wing-Shing","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon Chun-Kau","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-5197","authenticated-orcid":false,"given":"Kai-Ming","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8898-8505","authenticated-orcid":false,"given":"Cheuk-Chun","family":"Szeto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0602"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016040490"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.05.015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.10.017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.05.016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.360"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00164.2016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.033"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.06.027"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1021\/cr000110o"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/path.4692"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015050565"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03709-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.08.036"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-453-1_17"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2654"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.05.036"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00384"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08235-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.263"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2190"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00346.2002"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710396200"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6303"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.587840"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/kbr\/article-pdf\/48\/1\/241\/4113709\/000530210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/kbr\/article-pdf\/48\/1\/241\/4113709\/000530210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:21:44Z","timestamp":1745421704000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12,21]]},"published-print":{"date-parts":[[2023,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000530210","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}