{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:08:02Z","timestamp":1789517282346,"version":"build-2803163510"},"reference-count":32,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Patients with neuroendocrine neoplasms (NENs) may often develop other malignancies. This study aimed to identify the frequency at which these second malignancies occurred in England. Methods: Data were extracted from the National Cancer Registration and Analysis Service (NCRAS) on all patients diagnosed with a NEN at one of eight NEN site groups between 2012 and 2018: appendix, caecum, colon, lung, pancreas, rectum, small intestine, and stomach. WHO International Classification of Disease Edition-10 (ICD-10) codes were used to identify patients who had been diagnosed with an additional non-NEN cancer. Standardized incidence ratios (SIRs) for tumours diagnosed after the index NEN were produced for each non-NEN cancer type by sex and site. Results: A total of 20,579 patients were included in the study. The most commonly occurring non-NEN cancers after NEN diagnosis were the prostate (20%), lung (20%), and breast (15%). Statistically significant SIRs were observed for non-NEN cancer of the lung (SIR = 1.85, 95% CI: 1.55\u20132.22), colon (SIR = 1.78, 95% CI: 1.40\u20132.27), prostate (SIR = 1.56, 95% CI: 1.31\u20131.86), kidney (SIR = 3.53, 95% CI: 2.72\u20134.59), and thyroid (SIR = 6.31, 95% CI: 4.26\u20139.33). When stratified by sex, statistically significant SIRs remained for the lung, renal, colon, and thyroid tumours. Additionally, females had a statistically significant SIR for stomach cancer (2.65, 95% CI: 1.26\u20135.57) and bladder cancer (SIR = 2.61, 95% CI: 1.36\u20135.02). Conclusion: This study found that patients with a NEN experienced a metachronous tumour of the lung, prostate, kidney, colon, and thyroid at a higher rate than the general population of England. Surveillance and engagement in existing screening programmes are required to enable earlier diagnosis of second non-NEN tumours in these patients.<\/jats:p>","DOI":"10.1159\/000530238","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T18:00:40Z","timestamp":1679335240000},"page":"811-821","source":"Crossref","is-referenced-by-count":6,"title":["Second Primary Malignancies in Patients with a Neuroendocrine Neoplasm in England"],"prefix":"10.1159","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-8425","authenticated-orcid":false,"given":"Beth","family":"Russell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8705-7581","authenticated-orcid":false,"given":"Benjamin 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