{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:34:10Z","timestamp":1747193650112,"version":"3.40.5"},"reference-count":41,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Objectives: The aim of the study was to evaluate dosing of recombinant human luteinizing hormone (r-hLH) or human menopausal gonadotrophin (hMG)-derived medications with LH activity in ovarian stimulation (OS) cycles for in vitro fertilization (IVF)\/intracytoplasmic sperm injection (ICSI). Design: A non-interventional study was performed to analyse data from the German RecDate database (January 2007\u2013December 2011). Participants\/Materials, Setting, Methods: Starting\/total r-hLH\/hMG dose, OS duration\/cycle number, r-hLH\/hMG initiation day (first day of administration), and population\/cycle characteristics were assessed in women (\u226518 years) undergoing OS for IVF\/ICSI using r-hLH or hMG-derived medications (excluding corifollitropin alfa, clomiphene citrate, letrozole, mini\/micro-dose human chorionic gonadotrophin, and urofollitropin alone). Data were summarized descriptively. Results: 67,858 identified cycles utilized medications containing r-hLH (10,749), hMG (56,432), or both (677). Mean (standard deviation) OS duration with r-hLH and hMG was 10.1 (4.43) and 9.8 (6.16) days, respectively. Median (25th\u201375th percentile) r-hLH starting dose (75.0 [75.0\u2013150.0] IU) was consistent across patients regardless of age, infertility diagnosis, or gonadotrophin-releasing hormone (GnRH) protocol. Median (25th\u201375th percentile) hMG-derived LH activity starting dose was 225.0 (150.0\u2013300.0) IU, regardless of GnRH protocol, but was lower in women aged &amp;lt;35 years and those with ovulation disorders\/polycystic ovary syndrome. Median (25th\u201375th percentile) total dose for r-hLH (750.0 [337.5\u20131,125.0] IU) and hMG-derived LH activity (1,575.0 [750.0\u20132,625.0] IU) varied according to patients\u2019 age, infertility diagnosis, cycle number, and r-hLH\/hMG initiation day. GnRH antagonist use resulted in a numerically higher median total hMG-derived LH activity dose than GnRH agonist use. Limitations: The data used in this study were taken from electronic medical records relating to a specific timeframe (2007\u20132011) and therefore may not accurately reflect current clinical practice; however, it is likely that the differences between the two compounds would be maintained. Additionally, secondary data sources may suffer from uniformity and quality issues. Conclusions: The standard of care for OS cycles is described with respect to IVF\/ICSI treatment including an LH component in Germany during the specified timeframe. <\/jats:p>","DOI":"10.1159\/000530360","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T13:02:29Z","timestamp":1689166949000},"page":"214-225","source":"Crossref","is-referenced-by-count":0,"title":["Dosing Characteristics of Recombinant Human Luteinizing Hormone or Human Menopausal Gonadotrophin-Derived LH Activity in Patients Undergoing Ovarian Stimulation: A German Fertility Database Study"],"prefix":"10.1159","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-7911","authenticated-orcid":false,"given":"Valerie","family":"Strezsak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-0072","authenticated-orcid":false,"given":"Arthur","family":"Allignol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"B\u00fchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Longobardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Lispi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Schertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Verpillat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.20377\/jfr-235"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00065"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s1043-2760(03)00085-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174130"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41350"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S88904"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex234"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.02.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00387"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.18.03511-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)60865-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab065"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei348"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa183"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd012586"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.112"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.10.021"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.5.1507"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.12.2525"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802374815"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03299.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_79_17"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(04)10"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)62071-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.03.024"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00614"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17250"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-6"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2015.03.002"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.633128"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex321"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey061"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.485"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew051"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1210\/endo-53-6-604"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00114"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3275\/8657"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.06.041"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex208"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-1034-z"}],"container-title":["Gynecologic 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