{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:34:12Z","timestamp":1747193652479,"version":"3.40.5"},"reference-count":8,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>We present a case report of a patient with a rare high-grade transformation of an acinic cell carcinoma (ACC) of the parotid gland, who developed Cushing\u2019s syndrome (CS) as a result of ectopic secretion of adrenocorticotropic hormone by the tumour. The hypercortisolism was successfully treated with metyrapone, and the ACC was treated with local radiotherapy and a combined six cycles of gemcitabine and cisplatin, having achieved a partial response to the tumour. A multidisciplinary approach and combined medical treatment with radiotherapy and were essential for disease control and CS management. ACC should be considered in the differential diagnosis of ectopic CS. <\/jats:p>","DOI":"10.1159\/000530445","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T21:11:52Z","timestamp":1689887512000},"page":"538-542","source":"Crossref","is-referenced-by-count":0,"title":["Ectopic Cushing\u2019s Syndrome Secondary to Acinic Cell Carcinoma of the Parotid Gland: A Case Report"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-1969","authenticated-orcid":false,"given":"Pedro Miguel","family":"Antunes Meireles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Pessoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0481-8494","authenticated-orcid":false,"given":"Sara","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-5642","authenticated-orcid":false,"given":"Juliana Faria","family":"Filipe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-5905","authenticated-orcid":false,"given":"Miguel","family":"Rito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Sargento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2527"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9139-z"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0968"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2017.1373927"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s1658-3876(09)50035-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/2324709616674742"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12955"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2012.08.003"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/538\/4013261\/000530445.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/538\/4013261\/000530445.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:24:02Z","timestamp":1745421842000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":8,"URL":"https:\/\/doi.org\/10.1159\/000530445","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.23640984","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2023,7,13]]}}}