{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:21:46Z","timestamp":1768274506496,"version":"3.49.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Quantitative measurements of liver fat contents (LFCs) by magnetic resonance imaging derived-proton density fat fraction (MRI-PDFF) are accurate but limited by availability, convenience, and expense in the surveillance of metabolic associated fatty liver (MAFLD). Insulin resistance (IR) and steatosis-associated serum indices are useful in screening for MAFLD, but their value in monitoring MAFLD with or without chronic hepatitis B virus (CHB) infection remains unclear and we aimed to evaluate these scores in predicting changes in LFC. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a prospective study between January 2015 and December 2021 with 620 consecutive participants with MAFLD (212 participants with CHB) who received a 24-week lifestyle intervention. The homeostasis model assessment of IR (HOMA-IR), HOMA2 index, glucose-insulin ratio, quantitative insulin sensitivity check index, fasting insulin resistance index, fatty liver index (FLI), hepatic steatosis index (HSI), liver fat score (LFS), visceral adiposity index, and triglycerides * glucose were calculated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; When using endpoints such as LFS improvements of \u22655% or 10% or escalations of \u22655%, LFS had the highest area under the curve (AUC) values at all endpoints for MAFLD alone (0.756, 95% CI: 0.707\u20130.805; 0.761, 95% CI: 0.705\u20130.818; 0.807, 95% CI: 0.713\u20130.901, all &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.05, respectively). With CHB, the FLI (AUC = 0.750) and HIS (AUC = 0.770) exhibited the highest AUCs between the former two outcomes, respectively, but no score could predict LFC escalation of \u22655%. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Among IR and steatosis scores, changes in LFC through lifestyle interventions can be captured with LFS possessing moderate precision but not in those with CHB. <\/jats:p>","DOI":"10.1159\/000530531","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T21:00:35Z","timestamp":1694120435000},"page":"448-459","source":"Crossref","is-referenced-by-count":3,"title":["Comparisons of Insulin Resistance- and Steatosis-Based Scores in Monitoring Metabolic Associated Fatty Liver Disease Treatment Response"],"prefix":"10.1159","volume":"79","author":[{"given":"Junzhao","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yansong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congxian","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bihui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10094-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00570-y"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.07.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/js.2019-00052"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.178"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322572"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.01.027"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-6-33"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.061"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.08.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.06.005"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2019.04.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v12.i4.149"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0607-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/20406223211033119"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06072-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10017-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000504"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2019.12.007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.010"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01675-y"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-207"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801585"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31624"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/nu10020157"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13488"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2021.0314"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13161"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.636897"}],"container-title":["Annals 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