{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:51:47Z","timestamp":1776185507955,"version":"3.50.1"},"reference-count":41,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Connective tissue diseases (CTDs) are responsible for about 20% of interstitial lung disease (ILD) cases, but their diagnosis in a pulmonary unit (PU) is not always straightforward due to a heterogeneous clinical picture. Objectives: The aim of this study was to evaluate the clinical presentation of rheumatoid arthritis (RA) and CTD-ILD cases diagnosed in PU, compared to RA and CTD patients diagnosed in a rheumatologic unit (RU). Methods: Patients with RA, systemic sclerosis (SSc), primary Sj\u04e7gren\u2019s syndrome (pSS), and idiopathic inflammatory myopathy were retrospectively enrolled from an RU and a PU designated to manage ILD during a period from January 2017 to October 2022. The classification of CTD-PU was carried out in a multidisciplinary setting, including the same rheumatologists that diagnosed CTD in the RU. Results: ILD-CTD-PU patients were prevalently male and older. Progression from undifferentiated CTD to a specific condition was more common in ILD-CTD-PU, and those patients generally obtained a lower score on specific classification criteria. RA-PU patients resembled polymyalgia rheumatica in 47.6% of cases, also showing a greater proportion of typical joint deformities (p = 0.02). SSc-PU patients showed a usual interstitial pneumonia pattern in 76% of cases and, compared with SSc-RU, were more commonly seronegative (p = 0.03) and generally lacked fingertip lesions (p = 0.02). The majority of the diagnoses of pSS-PU were in patients with previously diagnosed ILD, in which seropositivity and sicca syndrome developed during follow-up. Conclusions: CTD-ILD patients diagnosed in the PU show severe lung involvement and a nuanced autoimmune clinical picture. <\/jats:p>","DOI":"10.1159\/000530785","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T21:23:56Z","timestamp":1687209836000},"page":"405-415","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Presentation of Connective Tissue Disease Patients with and without Interstitial Lung Disease: A Retrospective Study"],"prefix":"10.1159","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-1202","authenticated-orcid":false,"given":"Gianluca","family":"Sambataro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Libra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Spicuzza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7196-2974","authenticated-orcid":false,"given":"Stefano","family":"Palmucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3050-5440","authenticated-orcid":false,"given":"Paola","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-7616","authenticated-orcid":false,"given":"Eugenio","family":"Spagnolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Colaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-2729","authenticated-orcid":false,"given":"Lorenzo","family":"Malatino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8201-8404","authenticated-orcid":false,"given":"Domenico","family":"Sambataro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Vancheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2005230"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10040208"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8112013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171314"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/art.39859"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211468"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0180"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202108-979ED"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00016-2016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102458"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10050253"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.04.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0660-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/lycdca"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00150-2015"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2134119"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.08.2175"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/lqi6z7"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/art.39971"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.09.017"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9093033"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-021-00209-0"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216694"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217609"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05465-x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep253"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000247216"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew047"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02078-5"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01197-2017"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200203000-00004"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3601-1"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.102447"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-019-0179-2"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/res\/article-pdf\/102\/6\/405\/3960402\/000530785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/res\/article-pdf\/102\/6\/405\/3960402\/000530785.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:27:55Z","timestamp":1745422075000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,20]]},"published-print":{"date-parts":[[2023,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000530785","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}