{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:02Z","timestamp":1747193582932,"version":"3.40.5"},"reference-count":17,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>A 39-year-old male kidney transplant recipient with Down syndrome (DS) was admitted to our hospital for biopsy. He had proteinuria at age 9, was diagnosed with immunoglobulin A nephropathy (IgAN) at age 22, had a tonsillectomy at age 35, and underwent ABO-compatible kidney transplantation (from his mother) at age 36. His serum creatinine was stable at 2.21 mg\/dL 3 months after the kidney transplant, and his urine protein was 0.11 g\/day. A protocol biopsy was performed 7 months after the kidney transplant, and there was suspicion of early recurrence of IgAN. One year after the transplant, urine erythrocytes were elevated and proteinuria was 0.41 g\/day; at 3 years and 5 months after the kidney transplant, hematuria was evident along with proteinuria (0.74 g\/day). Therefore, an episode biopsy was performed. A total of 23 glomeruli were obtained, four of which exhibited global sclerosis; three others showed intra- and extracapillary proliferative glomerulonephritis compatible with IgAN recurrence. Here, we report a rare case of early recurrence of IgAN with disease progression despite tonsillectomy in a patient with DS. <\/jats:p>","DOI":"10.1159\/000530915","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T21:04:16Z","timestamp":1689887056000},"page":"35-40","source":"Crossref","is-referenced-by-count":0,"title":["Early Recurrence of Immunoglobulin A Nephropathy after Kidney Transplantation in a Patient with Down Syndrome"],"prefix":"10.1159","volume":"147","author":[{"given":"Yutaro","family":"Ohki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9856-0852","authenticated-orcid":false,"given":"Izumi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akimitsu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-369X","authenticated-orcid":false,"given":"Go","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudo","family":"Tanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Urabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Miki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-1553","authenticated-orcid":false,"given":"Takahiro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3905-9395","authenticated-orcid":false,"given":"Ichiro","family":"Ohkido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5407-5265","authenticated-orcid":false,"given":"Nobuo","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yokoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1706537"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.04.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2018.02.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.030"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1582-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194501"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00092"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.4772"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02068"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv221"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.158"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214256"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.20.183"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1619-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84715-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1628-z"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/nef\/article-pdf\/147\/Suppl.%201\/35\/4047809\/000530915.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/nef\/article-pdf\/147\/Suppl.%201\/35\/4047809\/000530915.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:29:30Z","timestamp":1745422170000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000530915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":17,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2023,11,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000530915","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"type":"print","value":"1660-8151"},{"type":"electronic","value":"2235-3186"}],"subject":[],"published":{"date-parts":[[2023]]}}}