{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:19:43Z","timestamp":1785161983857,"version":"3.55.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>ASPIRE, a three-part, international, phase 2 trial (ClinicalTrials.gov identifier: NCT01440374), investigated eltrombopag efficacy and safety in patients with advanced myelodysplastic syndrome or acute myeloid leukemia and grade 4 thrombocytopenia (&amp;lt;25 \u00d7 109 platelets\/L). Approximately 30\u201365% of patients in this open-label extension phase experienced clinically relevant thrombocytopenic events; no conclusions could be made regarding long-term efficacy (non-randomized design, no placebo control), and survival rates may simply reflect advanced disease. Long-term safety was consistent with the double-blind phase and contrasted with earlier SUPPORT study findings in higher-risk patients, suggesting that eltrombopag may have a role in treating thrombocytopenia in patients with low-\/intermediate-risk myelodysplastic syndrome. <\/jats:p>","DOI":"10.1159\/000531146","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T11:36:20Z","timestamp":1687174580000},"page":"373-378","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Safety and Efficacy of Eltrombopag for Advanced Myelodysplastic Syndromes or Acute Myeloid Leukemia and Severe Thrombocytopenia: Results of the ASPIRE Extension Study"],"prefix":"10.1159","volume":"146","author":[{"given":"Moshe","family":"Mittelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Grosicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Lawniczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Selleslag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30228-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2018.046"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000127"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30012-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.249995"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28663"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30016-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30017-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17539"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17538"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-855221"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/5\/373\/4014283\/000531146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/5\/373\/4014283\/000531146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:32:10Z","timestamp":1745422330000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000531146","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.22954532","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}