{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:45:43Z","timestamp":1790354743337,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Ingesting some foods can trigger headache attacks in migraine patients. Diet-sourced citrulline activates the &lt;sc&gt;l&lt;\/sc&gt;-arginine-nitric oxide pathway, acting on the pathophysiology of migraine. Methods: The study was a clinical trial, interventional, controlled, and with group comparison. The sample was non-random, composed of 38 volunteers with migraine and 38 without headache (control). Both groups ingested a portion of watermelon to determine the onset of headache attacks. Before and after ingesting watermelon, they underwent blood collections to determine serum nitrite levels. Results: There were 38 volunteers diagnosed with migraine without aura and 38 controls, whose mean age was, respectively, 22.4 \u00b1 1.5 and 22.9 \u00b1 3.1 years (p = 0.791). Headache was triggered by watermelon ingestion after 124.3 \u00b1 20.5 min of ingestion in 23.7% (9\/38) of the migraine volunteers and in none of the controls (p = 0.002). There was an increase in serum nitrite levels, both in migraine volunteers (23.4%) and in the control group (24.3%), after watermelon ingestion. This difference was significant (p &amp;lt; 0.001). Discussion: Watermelon ingestion triggered headache attacks in migraine patients and increased serum nitrite levels, attesting to a possible activation of the &lt;sc&gt;l&lt;\/sc&gt;-arginine-nitric oxide pathway. <\/jats:p>","DOI":"10.1159\/000531286","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T21:00:33Z","timestamp":1686862833000},"page":"250-255","source":"Crossref","is-referenced-by-count":9,"title":["Migraine Attacks Triggered by Ingestion of Watermelon"],"prefix":"10.1159","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-9679","authenticated-orcid":false,"given":"Raimundo Pereira","family":"Silva-N\u00e9to","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Leal","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Rebeca 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