{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:27:57Z","timestamp":1788838077694,"version":"build-2803163510"},"reference-count":35,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Low-grade inflammation is seen in many chronic illnesses, including chronic kidney disease (CKD). We have recently reported on beneficiary effects of anti-inflammatory treatment in the interleukin (IL-) 1 pathway on anemia as well as CKD extent in a mouse model. Colchicine has been shown to have beneficiary effects in several inflammatory conditions through various mechanisms, including inhibition of tubulin polymerization as well as caspase-1-mediated IL-1 activation. Methods: Kidney injury (KI) was induced by administering an adenine diet to 8-week-old C57BL\/6J mice treated with colchicine (Col) (30 \u00b5g\/kg) or saline injections for 3 weeks, generating 4 groups: C, Ccol, KI, and KIcol. Results: KI animals had an increase in inflammation indices in the blood (neutrophils), liver, and kidneys (uromodulin, IL-6, pSTAT3). Increased kidney tubulin polymerization and caspase-1 in KI, as well as kidney Mid88 and IRAK4 (downstream of IL-1), were inhibited in KIcol. Kidney macrophage and polymorphonuclear infiltration (positive for F4\/80 and MPO, respectively), the percentage of fibrotic area, and TGF\u03b2 mRNA levels were lower in KIcol versus KI. Conclusions: Colchicine inhibited tubulin polymerization and caspase-1 activation and attenuated kidney inflammation and fibrosis in a mouse model of adenine-induced KI. Given its reported safety profile for long-term anti-inflammatory therapy without increasing infection tendency, it may serve as novel therapeutic approach in CKD. <\/jats:p>","DOI":"10.1159\/000531313","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T21:01:15Z","timestamp":1692046875000},"page":"693-700","source":"Crossref","is-referenced-by-count":7,"title":["Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury"],"prefix":"10.1159","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-7891","authenticated-orcid":false,"given":"Daniel","family":"Landau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehoray","family":"Shukri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eden","family":"Arazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Tobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Segev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03500412"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2691"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1019"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016020177"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.025"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.040"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317108"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85778-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.06.013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2021372"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.12.027"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180123101313"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00057.2013"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-116"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.196"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H1978"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.4.821-846.2000"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-009-9190-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.134"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.07.017"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301681"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI87532"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98718-x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5414\/CN108343"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-014-0238-6"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.08.006"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78936-5"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.131"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.20"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900783"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1159\/000063299"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-015-3932-4"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/nef\/article-pdf\/147\/11\/693\/4042998\/000531313.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/nef\/article-pdf\/147\/11\/693\/4042998\/000531313.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:33:40Z","timestamp":1745422420000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,1]]},"published-print":{"date-parts":[[2023,11,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000531313","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}