{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:34:02Z","timestamp":1793860442529,"version":"4.6.1"},"reference-count":47,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: The gold standard for diagnosing neurosyphilis (NS) is currently unavailable; various laboratory parameters in cerebrospinal fluid (CSF) and blood can assist in the diagnosis. Methods: PubMed, Embase, and the Cochrane Library were searched. Studies utilizing laboratory tests to assist in the diagnosis of NS were included. The pooled indicators for diagnostic performance and their respective 95% confidence intervals (CIs) were calculated. We used the superiority index to test the superiority of a diagnostic test. Results: Eleven citations were included in the study. Albumin quotient, CSF-TPHA, CSF-EIA, CSF-LDH, CSF-WBC, CSF-CXCL13, FTA-ABS, CSF-PCR, RPR, CSF-TPPA, TRUST, and CSF-venereal diseases research laboratory (VDRL) were assessed in the studies included. The pooled estimates of sensitivity, specificity, AUC of SROC and their respective 95% CIs for CSF-TPPA and CSF-VDRL were 0.97 (0.17, 1.00), 0.84 (0.62, 0.95), 0.93 (0.91, 0.95) and 0.74 (0.59, 0.85), 0.99 (0.93, 1.00), 0.94 (0.91, 0.96), respectively. CSF-TPHA demonstrated the highest relative sensitivity. CSF-VDRL manifested the highest specificity. CSF-TPHA, TRUST, CSF-VDRL, CSF-EIA, and RPR ranked in the top five laboratory tests with superiority index. Conclusion: CSF-TPHA, TRUST, CSF-VDRL, CSF-EIA, and RPR indicate acceptable performance in detecting NS compared to other modalities. Comprehensive diagnostic strategies still play a significant role in the diagnosis of NS. <\/jats:p>","DOI":"10.1159\/000531341","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T06:58:00Z","timestamp":1691477880000},"page":"418-429","source":"Crossref","is-referenced-by-count":12,"title":["The Diagnostic Performance of Laboratory Tests of Neurosyphilis: A Systematic Review and Network Meta-Analysis"],"prefix":"10.1159","volume":"86","author":[{"given":"Duyu","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00100-21"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241572"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001364"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz331"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231029"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268819000281"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_28_21"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00183.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix799"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1901593"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPWSL3G8RXMCQR"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa306"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4088\/pcc.18l02399"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06264-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa349"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000982"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21913"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123153"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2011.01844.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669182"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.6339\/jds.2009.07(2).450"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1258\/0956462001915750"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20254"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181f42093"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.10.008"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/0956462413515452"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02522-13"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw499"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/srep33569"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001450"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-016-1583-7"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.598382"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1201"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1167"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00681-14"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/597580"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008510"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-020-00081-1"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0911149"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3062-4"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1258\/0956462011924065"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12734"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-000-0086-9"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ene\/article-pdf\/86\/6\/418\/4061964\/000531341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ene\/article-pdf\/86\/6\/418\/4061964\/000531341.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:33:54Z","timestamp":1745422434000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,18]]},"published-print":{"date-parts":[[2023,12,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000531341","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}