{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:50Z","timestamp":1745468690683,"version":"3.40.4"},"reference-count":46,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction: Esophageal hypersensitivity is associated with gastroesophageal reflux disease (GERD). Since sleep disturbance causes esophageal hypersensitivity, hypnotics may ameliorate GERD. However, zolpidem prolongs esophageal acid clearance. Lemborexant is a new hypnotic with higher efficacy and fewer adverse events than zolpidem. Therefore, the present study investigated the effects of lemborexant on GERD. Methods: Patients with heartburn and\/or regurgitation and insomnia who did not take acid suppressants or hypnotics in the last month were recruited. Symptom assessments using GerdQ and reflux monitoring were performed before and after a 28-day treatment with 5 mg lemborexant at bedtime. The primary outcome was a change in the total GerdQ score, excluding the score for insomnia. Secondary outcomes were changes in each GerdQ score and the following parameters on reflux monitoring: the acid exposure time (AET), number of reflux events (RE), acid clearance time (ACT), and post-reflux swallow-induced peristaltic wave (PSPW) index. Results: Sixteen patients (age 45.0 [33.3\u201356.0], 11 females [68.8%]) completed the intervention (1 patient did not tolerate the second reflux monitoring). The total GerdQ score, excluding the score for insomnia, did not significantly change (8.0 [6.0\u20139.0] before vs. 7.0 [6.3\u20139.0] after p = 0.16). GerdQ showed the significant attenuation of regurgitation (2.0 [2.0\u20133.0] vs. 1.0 [0\u20132.8] p = 0.0054) but not heartburn (2.5 [1.0\u20133.0] vs. 1.0 [0.3\u20132.0] p = 0.175). No significant differences were observed in AET, RE, ACT, or PSPW index before and after the intervention. Conclusion: Lemborexant attenuated regurgitation without the worsening of objective reflux parameters. A randomized placebo-controlled study is warranted in the future. <\/jats:p>","DOI":"10.1159\/000531412","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T21:04:16Z","timestamp":1689887056000},"page":"438-445","source":"Crossref","is-referenced-by-count":2,"title":["Lemborexant Attenuates Regurgitation without Worsening Objective Parameters on Reflux Monitoring in Patients with Gastroesophageal Reflux Disease and Insomnia: A Single-Arm Proof-of-Concept Study"],"prefix":"10.1159","volume":"104","author":[{"given":"Yoshimasa","family":"Hoshikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Momma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kawami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01751-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac207"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001382"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.09.039"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000627"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.04.026"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02573.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1658"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000322"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00878-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/2050640613485238"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1417-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04142.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-022-00956-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01608-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.09.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033290"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322627"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4139-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.06.026"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302645"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19183"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000276"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.012"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.03.063"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12204"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.015"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.01.022"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.009"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.07.007"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321395"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98169-4"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07260-3"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01659-y"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9994"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-021-00880-8"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-021-00825-1"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-021-00845-x"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9150"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.003"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.310"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1159\/000524766"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/104\/6\/438\/4054516\/000531412.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/104\/6\/438\/4054516\/000531412.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:34:35Z","timestamp":1745422475000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\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