{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:34:09Z","timestamp":1747193649136,"version":"3.40.5"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Trifluridine\/tipiracil is approved for the use in later or last-line setting in previously treated metastatic colorectal cancer (mCRC) patients who progressed on standard anti-tumor drugs including 5-fluorouracil (5-FU), irinotecan, oxaliplatin, anti-VEGF and anti-EGFR antibodies, or who are not considered candidates for those standard therapies. In this report, we describe a 67-year-old male patient with &lt;i&gt;KRAS&lt;\/i&gt;-mutated mCRC and metachronous liver and lung metastasis who failed prior 5-FU- and irinotecan-containing regimens, but then showed long-term disease control for 31 months on single-agent trifluridine\/tipiracil given as second-line treatment. According to our experience, trifluridine\/tipiracil is a feasible and effective treatment option in earlier but not necessarily last-line therapy in mCRC patients who are not considered candidates for doublet or triplet chemotherapy. Besides its efficacy, it is associated with maintained quality of life and a manageable toxicity profile. Considering increasing age of mCRC patients and their wish for maintaining an independent lifestyle, further research on the use of trifluridine\/tipiracil in earlier lines of systemic mCRC therapy is warranted. <\/jats:p>","DOI":"10.1159\/000531525","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"27-34","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Progression-Free Survival of a Pre-Treated Patient with Metastatic Colorectal Cancer Receiving Trifluridine\/Tipiracil"],"prefix":"10.1159","volume":"69","author":[{"given":"Gerlinde Maria","family":"Michl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian M.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Nouriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Ladurner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Reisl\u00e4nder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4198-3627","authenticated-orcid":false,"given":"Marlies","family":"Michl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp130"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-019-02278-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw235"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1414325"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.10.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.3245"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100391"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9189483"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24412"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-2952(00)00253-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0573"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1605192"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28030208"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00334-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09892-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13551"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1701\/3827.38112"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000698"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3747\/co.27.6533"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10489-4"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/che\/article-pdf\/69\/1\/27\/4172690\/000531525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/che\/article-pdf\/69\/1\/27\/4172690\/000531525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:36:14Z","timestamp":1745422574000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,19]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,26]]},"published-print":{"date-parts":[[2024,2,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000531525","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2023,6,19]]}}}