{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:26:07Z","timestamp":1792167967742,"version":"4.4.0"},"reference-count":34,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: Retinopathy of prematurity (ROP) is the most common cause of preventable blindness in preterm infants. First-line treatments include intravitreal bevacizumab (IVB) or laser photocoagulation (LPC). Objectives: The aim of the study was to evaluate neurodevelopmental safety of IVB compared to LPC for ROP. Methods: MEDLINE, Embase, and Cochrane library were searched up to September 2022. Studies were included with at least 12-month follow-up of primary outcomes such as severe neurodevelopmental impairment (sNDI), cerebral palsy (CP), and hearing impairment (HI). Secondary outcomes were moderate-to-severe neurodevelopmental impairment (msNDI), Bayley Scores of Infant Development (BSID-III), and visual impairment. Results: 1,231 patients from 11 comparative studies were included. Quality of evidence was rated low for all outcomes. IVB was associated with a higher risk for sNDI (risk ratio [RR] = 1.25, 95% confidence interval [CI]: [1.01, 1.53], p = 0.04); and CP (RR = 1.40, CI: [1.08, 1.81], p = 0.01) compared to LPC. There was no significant difference between IVB and LPC for msNDI (RR = 1.15, CI: [0.98, 1.35], p = 0.08) and HI (RR = 1.43, CI: [0.86, 2.39], p = 0.17). BSID-III percentile scores were similar between IVB and LPC, with weighted mean differences of 1.51 [CI = \u22121.25, 4.27], 2.43 [CI = \u22121.36, 6.22], and 1.97 [CI = \u22121.06, 5.01] for cognitive, language, and motor domains, respectively (p &amp;gt; 0.05). Conclusion: To our knowledge, this is the largest meta-analysis on neurodevelopmental outcomes and the first to rigorously examine IVB monotherapy in ROP treatment. Compared to LPC, there was a marginally increased risk for sNDI and CP with IVB but little or no difference in the risk of msNDI and HI. Further randomized studies are needed to strengthen these findings. <\/jats:p>","DOI":"10.1159\/000531541","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T21:01:23Z","timestamp":1691787683000},"page":"577-588","source":"Crossref","is-referenced-by-count":13,"title":["A Meta-Analysis of Neurodevelopmental Outcomes following Intravitreal Bevacizumab for the Treatment of Retinopathy of Prematurity"],"prefix":"10.1159","volume":"120","author":[{"given":"Abed A.","family":"Baiad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-0854","authenticated-orcid":false,"given":"Imaan Z.","family":"Kherani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko M.","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Katsnelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev H.","family":"Muni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiar","family":"Mireskandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin N.","family":"Tehrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwei Ellen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Kertes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1413"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.205"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31344-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.07.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.0030"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1283-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4445-12.2013"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02045.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.01931.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-00884-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.11.012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S378520"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.06.034"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1888913"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05137-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1710556"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0420-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3537"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2017.10.006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3218"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223972"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.03.048"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm189"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148019"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2018.42.2.313"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230678"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2014.941070"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20190605-01"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00195-4"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/neo\/article-pdf\/120\/5\/577\/4024510\/000531541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/neo\/article-pdf\/120\/5\/577\/4024510\/000531541.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:36:21Z","timestamp":1745422581000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,2]]},"published-print":{"date-parts":[[2023,10,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000531541","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.23666733","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}