{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:20:31Z","timestamp":1760080831305,"version":"3.40.5"},"reference-count":63,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Ischemia\/reperfusion (I\/R) induced ovarian damage is caused by various diseases such as ovarian torsion, ovarian transplantation, cardiovascular surgery, sepsis, or intra-abdominal surgery. I\/R-related oxidative damage can impair ovarian functions, from oocyte maturation to fertilization. This study investigated the effects of dexmedetomidine (DEX), which has been shown to exhibit antiapoptotic, anti-inflammatory, and antioxidant effects, on ovarian I\/R injury. We designed four study groups: group 1 (n = 6): control group; group 2 (n = 6): only DEX group; group 3 (n = 6): I\/R group; group 4 (n = 6): I\/R + DEX group. Then, ovarian samples were taken and examined histologically and immunohistochemically, and tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured. In the I\/R group MDA levels, caspase-3, NF-\u03baB\/p65, 8-OHdG positivity, and follicular degeneration, edema, and inflammation were increased compared to the control group (p = 0.000). In addition, GSH levels were significantly decreased in the I\/R group compared to the control group (p = 0.000). On the other hand, in the I\/R + DEX treatment group MDA levels, caspase-3, NF-\u03baB\/p65, 8-OHdG positivity, follicular degeneration, edema, and inflammation findings were decreased than in the I\/R group (p = 0.000, p = 0.005, p = 0.005, p = 0.001, p = 0.005, respectively). However, GSH levels increased significantly in the I\/R + DEX treatment group compared to the I\/R group (p = 0.000). DEX protects against ovarian I\/R injury through antioxidation and by suppressing inflammation and apoptosis. <\/jats:p>","DOI":"10.1159\/000531613","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T21:00:31Z","timestamp":1687294831000},"page":"554-566","source":"Crossref","is-referenced-by-count":2,"title":["The Effects of Dexmedetomidine on Abdominal Aortic Occlusion-Induced Ovarian Injury via Oxidative Stress and 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