{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:59:38Z","timestamp":1758279578154,"version":"3.40.5"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The association between the use of cilostazol as a post-stroke antiplatelet medication and a reduction in post-stroke pneumonia has been suggested. However, whether cilostazol has a greater preventive effect against post-stroke aspiration pneumonia (AP) than other antiplatelet medications remains unclear. Thus, this study aimed to evaluate whether cilostazol has a greater preventive effect against post-stroke AP than aspirin or clopidogrel. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Through the Japanese Diagnosis Procedure Combination database, we identified patients who were hospitalized for ischemic stroke between April 2012 and September 2019. We performed 1:1 propensity score matching between patients who received cilostazol alone at discharge and those who received aspirin or clopidogrel alone at discharge. The primary outcome was the 90-day readmission for post-stroke AP. The occurrence of recurrent ischemic stroke within 90 days was also evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among the 305,543 eligible patients with ischemic stroke, 65,141 (21%), 104,157 (34%), and 136,245 (45%) received cilostazol, aspirin, and clopidogrel, respectively. Propensity score matching generated 65,125 pairs. The cilostazol group had a higher proportion of 90-day post-stroke readmissions with AP than the aspirin or clopidogrel groups (1.5% vs. 1.2%, &lt;i&gt;p&lt;\/i&gt; &amp;lt; 0.001). The proportion of patients with recurrent ischemic stroke within 90 days was also higher in the cilostazol group (2.4% vs. 2.2%, &lt;i&gt;p&lt;\/i&gt; = 0.017). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The present study suggests that cilostazol may not have a greater effect on preventing post-stroke AP within 90 days than other antiplatelet medications. Nevertheless, further randomized controlled trials with longer follow-up periods are warranted. <\/jats:p>","DOI":"10.1159\/000531716","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:05Z","timestamp":1697058185000},"page":"152-159","source":"Crossref","is-referenced-by-count":1,"title":["Cilostazol versus Aspirin or Clopidogrel for Reducing Post-Stroke Aspiration Pneumonia: A Nationwide Retrospective Cohort Study"],"prefix":"10.1159","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-6835","authenticated-orcid":false,"given":"So","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Yamana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Kumazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fushimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016758"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.207.3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49140.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000092922"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s41479-018-0046-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7223\/apjdm.7.19"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31826fd541"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002736"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13777"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.19.5.604"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000091226"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.je.2016.09.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268481"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.07.011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104444"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.07.044"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.049"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.1.R76"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02341-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70094-2"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ced\/article-pdf\/53\/2\/152\/4187197\/000531716.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ced\/article-pdf\/53\/2\/152\/4187197\/000531716.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:38:12Z","timestamp":1745422692000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,16]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4,2]]},"published-print":{"date-parts":[[2024,3,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000531716","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"type":"print","value":"1015-9770"},{"type":"electronic","value":"1421-9786"}],"subject":[],"published":{"date-parts":[[2023,8,16]]}}}