{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:32:48Z","timestamp":1768555968706,"version":"3.49.0"},"reference-count":19,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Primary transitional cell carcinoma of the ureter is a rare type of cancer with metastasis presented in approximately 25% at diagnosis. Due to its rarity and poor prognosis, the management of this neoplasm is still controversial, and the development of new therapies is of uttermost importance. Herein, we describe a case of a 54-year-old patient diagnosed with transitional cell carcinoma of the left ureter submitted to left nephroureterectomy (pT3N2M0) and methotrexate, vinblastine, doxorubicin, and cisplatin adjuvant chemotherapy. A single liver metastasis was detected and combination chemotherapy with gemcitabine and carboplatin was initiated along with stereotactic body radiation therapy. Despite these 2 previous chemotherapy regimens, the patient presented disease progression and transarterial selective internal radiation therapy (SIRT) with yttrium-90 was indicated. This locoregional treatment was performed with the administration of 1.2 GBq yttrium-90 resin microspheres (SIR-Spheres\u00ae, Sirtex Medical Limited, Sydney, NSW, Australia) into the right hepatic artery. Another systemic treatment was immunotherapy using nivolumab with excellent tolerability. After 10 years of follow-up, at the last clinical evaluation, the patient had no clinical symptoms and the last imaging follow-up using positron emission tomography-computed tomography scan showed complete response. This report introduces upper urinary tract urothelial carcinoma as a distinct type of malignancy in which SIRT can be safely implemented. As a transition method to nivolumab, it was successful. There might be a potential therapeutic synergism between these 2 treatment modalities. <\/jats:p>","DOI":"10.1159\/000531787","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:07:23Z","timestamp":1697058443000},"page":"711-717","source":"Crossref","is-referenced-by-count":2,"title":["Transarterial Selective Internal Radiation Therapy with Yttrium-90 for Liver Metastatic Urothelial Carcinoma of the Ureter as a Bridging Therapy to Immunotherapy: A Case Report with a 10-Year Follow-Up"],"prefix":"10.1159","author":[{"given":"Bruno Pagnin","family":"Schmid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Juliano","family":"Silva Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Guedes","family":"Moreira Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Leonardo","family":"Galastri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno Boueri","family":"Affonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Mina","family":"Falsarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Aliosha","family":"Kaliks Guendelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Gobbo","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19623"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v5.i2.158"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13826"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(17)30065-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30202-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.723066"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050842"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.09.031"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.31744\/einstein_journal\/2020RC4990"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13444"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010055"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2020.06.008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.018"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1564-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2019.09.236"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061557"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2020.07.009"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-022-03228-6"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/705\/3991624\/000531787.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/16\/1\/705\/3991624\/000531787.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:39:14Z","timestamp":1745422754000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":19,"URL":"https:\/\/doi.org\/10.1159\/000531787","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.23950767","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,24]]}}}