{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T12:28:04Z","timestamp":1750249684649,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2023]]},"abstract":"<b><i>Introduction:<\/i><\/b> Haemato-oncologic patients are more susceptible to severe infections with SARS-CoV-2. We aimed to assess the clinical outcomes of SARS-CoV-2 infection among patients with Mycosis Fungoides and Sezary Syndrome (MF\/SS). <b><i>Methods:<\/i><\/b> The data were retrieved from anonymized electronic medical records of Maccabi Healthcare Services (MHS), the second-largest healthcare organization in Israel. Patients diagnosed with MF\/SS were included in the study. COVID-19 PCR test results together with sociodemographic and clinical data were extracted and analyzed to evaluate the association of COVID-19 with clinical outcomes. <b><i>Results:<\/i><\/b> In the period of 2020\u20132022, 1,472 MF\/SS patients were included in the study. Among them, 768 (52%) had SARS-CoV-2 infection. The hospitalization rate was 2.9% and infection by the Delta variant was associated with the highest hospitalization rate (7.7%). The hospitalization rate was lower among fully vaccinated patients (<i>p<\/i> = 0.032) but higher for patients older than 65 (<i>p<\/i> &lt; 0.001) and patients with SS (vs. MF) (<i>p<\/i> &lt; 0.001) or COPD (<i>p<\/i> = 0.024) diagnosis. There was a tendency for decreased hospitalization among patients treated with nirmatrelvir + ritonavir within 5 days of infection, with a 79% risk reduction, although it was not statistically significant (<i>p<\/i> = 0.164). <b><i>Conclusion:<\/i><\/b> Patients with MF\/SS do not necessarily have worse COVID-19 outcomes compared to the general population. <\/jats:p>","DOI":"10.1159\/000531831","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T06:58:00Z","timestamp":1691477880000},"page":"496-503","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome"],"prefix":"10.1159","volume":"146","author":[{"given":"Ilana","family":"Levy Yurkovski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Rokach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Melamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillel","family":"Alapi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivan","family":"Gazit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Patalon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Tadmor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003170"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0931-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-020-00177-z"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1966782"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279196"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1101\/2021.04.06.21254949"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.763412"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25577"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-00809-w"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14463"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17430"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2022.04.008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-020-05207-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac279"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012251"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17458"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102780"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3775"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/6\/496\/4118414\/000531831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/aha\/article-pdf\/146\/6\/496\/4118414\/000531831.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:39:44Z","timestamp":1745422784000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000531831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,22]]},"published-print":{"date-parts":[[2023,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000531831","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2023]]}}}